Intercellular communication in many organs is maintained via intercellular gap junction channels composed of connexins, a large protein family with a number of isoforms. This gap junction intercellular communication (GJIC) allows the propagation of action potentials (e.g., in brain, heart), and the transfer of small molecules which may regulate cell growth, differentiation and function. The latter has been shown to be involved in cancer growth: reduced GJIC often is associated with increased tumor growth or with de-differentiation processes. Disturbances of GJIC in the heart can cause arrhythmia, while in brain electrical activity during seizures seems to be propagated via gap junction channels. Many diseases or pathophysiological conditions seem to be associated with alterations of gap junction protein expression. Thus, depending on the target disease opening or closure of gap junctions may be of interest, or alteration of connexin expression. GJIC can be affected acutely by changing gap junction conductance or--more chronic--by altering connexin expression and membrane localisation. This review gives an overview on drugs affecting GJIC.
Influence of the sodium pump on intercellular communication in heart fibres: effect of intracellular injection of sodium ion on electrical coupling
The role of the renin-angiotensin system in the control of cell communication in the heart: effects of enalapril and angiotensin II
Cardiac gap junctions: three distinct single channel conductances and their modulation by phosphorylating treatments
Intracardiac detection of angiotensinogen and renin: a localized renin-angiotensin system in neonatal rat heart
Dependence of junctional conductance on proton, calcium and magnesium ions in cardiac paired cells of guinea-pig
Electrical properties of gap junction channels in guinea-pig ventricular cell pairs revealed by exposure to heptanol.
Effects of increasing intercellular resistance on transverse and longitudinal propagation in sheep epicardial muscle
Cell pairs isolated from adult guinea pig and rat hearts: effects of [Ca2+]i on nexal membrane resistance
Ungulate cardiac purkinje fibres: the influence of intracellular pH on the electrical cell-to-cell coupling
Studies on heart. XIX. Isolation of an atrial peptide that improves the rhythmicity of cultured myocardial cell clusters
Oleic acid differentially affects gap junction-mediated communication in heart and vascular smooth muscle cells
Regulation of gap junctional coupling in isolated pancreatic acinar cell pairs by cholecystokinin-octapeptide, vasoactive intestinal peptide (VIP) and a VIP-antagonist
TPA increases conductance but decreases permeability in neonatal rat cardiomyocyte gap junction channels
Multisubunit assembly of an integral plasma membrane channel protein, gap junction connexin43, occurs after exit from the ER
Basic fibroblast growth factor stimulates connexin-43 expression and intercellular communication of cardiac fibroblasts
Identification of novel DNA binding targets and regulatory domains of a murine tinman homeodomain factor, nkx-2.5.
The uncoupling effect of diacylglycerol on gap junctional communication of mammalian heart cells is independent of protein kinase C
Selective block of gap junction channel expression with connexin-specific antisense oligodeoxynucleotides
A new synthetic antiarrhythmic peptide reduces dispersion of epicardial activation recovery interval and diminishes alterations of epicardial activation patterns induced by regional ischemia. A mapping study
A structural basis for the unequal sensitivity of the major cardiac and liver gap junctions to intracellular acidification: the carboxyl tail length
Specific motifs in the external loops of connexin proteins can determine gap junction formation between chick heart myocytes
Differential regulation of distinct types of gap junction channels by similar phosphorylating conditions
Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase.
Regulation of cardiac gap junction channel permeability and conductance by several phosphorylating conditions
Cyclic AMP induces rapid increases in gap junction permeability and changes in the cellular distribution of connexin43
Functional and structural assessment of intercellular communication. Increased conduction velocity and enhanced connexin expression in dibutyryl cAMP-treated cultured cardiac myocytes
Activation of protein kinase C in human uterine smooth muscle induces connexin-43 gene transcription through an AP-1 site in the promoter sequence.
Improving cardiac gap junction communication as a new antiarrhythmic mechanism: the action of antiarrhythmic peptides.
Inferring connection proximity in networks of electrically coupled cells by subthreshold frequency response analysis.
Physiological and physiopathological aspects of connexins and communicating gap junctions in spermatogenesis.
Ca²⁺-dependent nitric oxide release in the injured endothelium of excised rat aorta: a promising mechanism applying in vascular prosthetic devices in aging patients
Myocardial Ca2+ handling and cell-to-cell coupling, key factors in prevention of sudden cardiac death
Melatonin attenuates hypertension-related proarrhythmic myocardial maladaptation of connexin-43 and propensity of the heart to lethal arrhythmias
Cell-cell communication enhances the capacity of cell ensembles to sense shallow gradients during morphogenesis
ATP release by cardiac myocytes in a simulated ischaemia model: inhibition by a connexin mimetic and enhancement by an antiarrhythmic peptide
Properties of gap junction blockers and their behavioural, cognitive and electrophysiological effects: animal and human studies
Connexin 43 mimetic peptides inhibit spontaneous epileptiform activity in organotypic hippocampal slice cultures
Negative growth control of osteosarcoma cell by Bowman-Birk protease inhibitor from soybean; involvement of connexin 43
The signal transduction cascade regulating the expression of the gap junction protein connexin43 by beta-adrenoceptors.
Cytoplasmic accumulation of connexin32 protein enhances motility and metastatic ability of human hepatoma cells in vitro and in vivo
The unstoppable connexin43 carboxyl-terminus: new roles in gap junction organization and wound healing
Dye coupling and connexin expression by cortical radial glia in the early postnatal subventricular zone
Up-regulated inflammatory factors endothelin, NFkappaB, TNFalpha and iNOS involved in exaggerated cardiac arrhythmias in l-thyroxine-induced cardiomyopathy are suppressed by darusentan in rats
Palmitoleic acid induces the cardiac mitochondrial membrane permeability transition despite the presence of L-carnitine
Remodeling of cardiac passive electrical properties and susceptibility to ventricular and atrial arrhythmias
Characterizing the mode of action of extracellular Connexin43 channel blocking mimetic peptides in an in vitro ischemia injury model
Altered thyroid status affects myocardial expression of connexin-43 and susceptibility of rat heart to malignant arrhythmias that can be partially normalized by red palm oil intake
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