Pharmacology of pentoxifylline in isolated canine arteries and veins.

Journal of Cardiovascular Pharmacology
U HoeffnerP M Vanhoutte

Abstract

Pentoxifylline possesses vasodilator properties, but little information is available on the mechanism of action explaining this vasodilator effect. The present experiments were designed to determine the effects of the compound on vascular smooth muscle, endothelium, and adrenergic nerves in rings of isolated canine blood vessels. Pentoxifylline did not affect basal tension in coronary and femoral arteries or in saphenous and mesenteric veins; it did not alter the rhythmic activity of the latter, but did cause endothelium-independent relaxations of unstimulated basilar arteries. In coronary arteries and saphenous veins, but not femoral arteries contracted with prostaglandin F2 alpha, the compound caused relaxations which were not affected by propranolol or by removal of the endothelium. Pentoxifylline inhibited the endothelium-dependent contractions to the Ca2(+)-ionophore A23187 in the basilar artery. In saphenous veins (with endothelium), pentoxifylline did not inhibit responses to high K+, electrical stimulation of the adrenergic nerves, or exogenous norepinephrine (NE); it reduced contractions evoked by xylazine and hypoxia. In the basilar artery and the saphenous vein, the inhibitory effect of pentoxifylline was prevented b...Continue Reading

Citations

Feb 1, 1996·Critical Care Medicine·A D KayeB D Nossaman
May 1, 1997·Clinical and Experimental Pharmacology & Physiology·I KaputluA Boz
Jul 1, 1994·Journal of Basic and Clinical Physiology and Pharmacology·I Kaputlu, G Sadan
Feb 1, 1993·The Annals of Thoracic Surgery·M CarrierC L Pelletier
Apr 1, 1993·Journal of the American Geriatrics Society·S G Korenman, S P Viosca
Oct 12, 2011·The Veterinary Journal·N KabbeshM Y Mallem
Nov 3, 2016·Journal of Hypertension·Daniel BrieUNKNOWN Lipid, Blood Pressure Meta-analysis Collaboration (LBPMC) Group

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