Pharmacology of the adrenoceptors and cholinoceptors of the BC3H1 nonfusing muscle cell line

British Journal of Pharmacology
J P MaugerM Worcel

Abstract

1. We have studied the action of different transmitters on the transmembrane 42K or 86Rb efflux from tissue cultures of the BC3H1 muscle cell line. 2. The effect of catecholamines and carbachol (CCh) on the isotope efflux rate was measured by addition of the drugs at different times during the washout. 3. Noradrenaline (NA), phenylephrine (Phe), isoprenaline (Iso) and CCh increased 42K and 86Rb efflux rate in a dose-dependent manner. 4. The action of NA seems to be due exclusively to the stimulation of alpha-receptors, since its effect was blocked by phentolamine but not by propranolol. The effects of Iso on the 86Rb efflux were inhibited by propranolol. The beta-receptors in the BC3H1 cells seem to be the beta2-type since they are stimulated by Iso and insensitive to NA. 5. The effect of CCh was blocked (+)-tubocurarine but not by atropine. This result confirms the presence of nicotinic receptors in BC3H1 cells.

References

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Citations

Sep 25, 1981·Molecular and Cellular Biochemistry·V I TeichbergA Luini
Jan 1, 1986·Journal of Steroid Biochemistry·A M MouraM Worcel
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·A LuiniV I Teichberg
May 1, 1989·British Journal of Pharmacology·C D FosterA F Brading
Mar 1, 1985·Hypertension·J P GrünfeldM Worcel

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