Pharmacology of the paclitaxel-cisplatin, gemcitabine-cisplatin, and paclitaxel-gemcitabine combinations in patients with advanced non-small cell lung cancer

Cancer Chemotherapy and Pharmacology
J R KroepG J Peters

Abstract

To compare the pharmacology of the paclitaxel-cisplatin, gemcitabine-cisplatin and paclitaxel-gemcitabine combinations in patients with advanced non-small cell lung cancer (NSCLC). Twenty-four chemo-naive patients with advanced NSCLC were randomized to receive one of the three regimens. Plasma pharmacokinetics and pharmacologic parameters in mononuclear cells were compared and related to toxicity and efficacy. Pharmacological parameters of gemcitabine and cisplatin were not influenced by the combination with one of the other agents, while the paclitaxel clearance was significantly lower for the combination with cisplatin as compared to gemcitabine (P=0.024). The percentage decrease in platelets was significantly higher for the gemcitabine combinations (P=0.004) and related to the dFdCTP-Cmax (P=0.030). Pharmacologic parameters were not related to response or survival. Gemcitabine and cisplatin pharmacology were not influenced by the combination with one of the other agents, while paclitaxel has a lower clearance in combination with cisplatin as compared to gemcitabine.

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Citations

Mar 24, 2016·Cancer Chemotherapy and Pharmacology·Joseph CiccoliniElisa Giovannetti
Jun 10, 2014·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Zakhar LysovPatricia C Liaw
Jun 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jens VoortmanGiuseppe Giaccone

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