Pharmacology, Systematic Review and Recent Clinical Trials of Metadoxine

Reviews on Recent Clinical Trials
Mathieu Di Miceli, Benjamin Gronier

Abstract

Metadoxine is composed of pyroglutamic acid and vitamin B6. Administrations of metadoxine are indicated in cases of acute alcohol intoxication or in chronic alcoholism. To reference all available clinical trials investigating the effects of metadoxine on humans. A focus was put on alcohol intoxication and chronic alcoholism, alcohol abstinence and survival rates. Adverse events were also taken into consideration. Finally, potential roles of metadoxine in treating disorders of the central nervous system will be assessed. PRISMA guidelines were followed. Computerised literature searches were performed in July 2017 to retrieve all clinical trials investigating metadoxine from the MEDLINE®, the European Union Clinical Trials Register and the ClinicalTrials.gov databases, using the following equation: "metadoxine". Inclusion criteria were all published clinical trials investigating metadoxine in humans, regardless of outcome measures. Exclusion criteria were articles not abstracted, in vitro studies, studies in rodents, retrospective studies and reviews. Sixteen studies were included. Evidence suggests that metadoxine appears safe to use, as it rarely induced adverse events (reported in 7 out of the 7 studies measuring safety/tolera...Continue Reading

Citations

Sep 22, 2020·Clinical and Molecular Hepatology·Yun Seok Kim, Sang Geon Kim
Apr 9, 2021·Nature Reviews. Neuroscience·Pan-Yue Deng, Vitaly A Klyachko

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