Pharmacology, tolerance, and antiviral activity of vidarabine monophosphate in humans.

Antimicrobial Agents and Chemotherapy
R J WhitleyR A Buchanan

Abstract

Vidarabine (adenine arabinoside) is a purine nucleoside useful in humans for therapy of herpes simplex virus encephalitis and herpes zoster virus infections in immunocompromised patients. However, the potential usefulness of vidaribine is limited by its poor solubility, which requires continuous infusion in relatively large volumes of intravenous fluid. Vidarabine 5'-monophosphate is highly soluble and has the advantage that it can be administered intermittently intramuscularly or intravenously. In a clinical, pharmacokinetic study, plasma levels and urinary excretion of vidarabine 5'-monophosphate were determined after intravenous and intramuscular administration in 29 immunosuppressed patients with herpes simplex or zoster virus infections at dosages of 15 to 30 mg/kg per day administered for 5 days. As determined by high-pressure liquid chromatography, vidarabine 5'-monophosphate was metabolized in a fashion comparable to the metabolism of vidarabine and its major metabolite in plasma was arabinosyl hypoxanthine. After administration, 40 to 50% of the vidarabine 5'-monophosphate was recovered from the urine as arabinosyl hypoxanthine, and 3 to 4% was recovered as vidarabine. Determinations of areas under the curve for arabin...Continue Reading

References

Jan 5, 1979·JAMA : the Journal of the American Medical Association·S L SacksW S Robinson
Jul 1, 1974·The Journal of Infectious Diseases·L T Ch'ienC A Alford
May 1, 1980·Clinical Pharmacology and Therapeutics·R A BuchananR J Whitley

❮ Previous
Next ❯

Citations

Apr 29, 1983·Pharmaceutisch Weekblad. Scientific Edition·L M StolkA Vyth
Jun 22, 1984·Pharmaceutisch Weekblad. Scientific Edition·M S Kwee, L M Stolk
Apr 1, 1984·Clinics in Dermatology·M Seidlin, S E Straus
Sep 1, 1984·Lancet·K G Nicholson
Jan 1, 2009·Nucleosides, Nucleotides & Nucleic Acids·Wei ShenJohn Hilfinger
Jan 1, 1992·Fundamental & Clinical Pharmacology·F FauvelleO Petitjean
Dec 1, 2010·Marine Drugs·Sunil SagarKenneth P Minneman
Nov 1, 1995·The Journal of Dermatology·L P GangarosaJ M Hill
Jul 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A PonzettoE Chiaberge
Nov 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J H HoofnagleK Ishak
Jul 1, 1981·Hospital Practice·R J Whitley, C A Alford
Mar 13, 2018·Frontiers in Physiology·Joanne J A van BavelMarcel A G van der Heyden
Oct 12, 2018·Proceedings of the National Academy of Sciences of the United States of America·Kirsten M KnechtYong Xiong
Aug 31, 2020·Medicine in Drug Discovery·Hanxiao YuWenjun Tang
Jul 3, 2021·Viruses·Lauren A SadowskiBarry J Margulies

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.