Pharmacomicrobiomics in inflammatory arthritis: gut microbiome as modulator of therapeutic response

Nature Reviews. Rheumatology
Jose U ScherSteven B Abramson

Abstract

In the past three decades, extraordinary advances have been made in the understanding of the pathogenesis of, and treatment options for, inflammatory arthritides, including rheumatoid arthritis and spondyloarthritis. The use of methotrexate and subsequently biologic therapies (such as TNF inhibitors, among others) and oral small molecules have substantially improved clinical outcomes for many patients with inflammatory arthritis; for others, however, these agents do not substantially improve their symptoms. The emerging field of pharmacomicrobiomics, which investigates the effect of variations within the human gut microbiome on drugs, has already provided important insights into these therapeutics. Pharmacomicrobiomic studies have demonstrated that human gut microorganisms and their enzymatic products can affect the bioavailability, clinical efficacy and toxicity of a wide array of drugs through direct and indirect mechanisms. This discipline promises to facilitate the advent of microbiome-based precision medicine approaches in inflammatory arthritis, including strategies for predicting response to treatment and for modulating the microbiome to improve response to therapy or reduce drug toxicity.

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Citations

Nov 14, 2020·Current Opinion in Rheumatology·Shahna Tariq, Alison H Clifford
Feb 10, 2021·Nature Reviews. Rheumatology·Sarah Onuora
Nov 19, 2020·Nutrients·Eduardo DouradoJoão Eurico Fonseca
Feb 18, 2021·European Journal of Immunology·Carolin BrandlMario M Zaiss
Mar 7, 2021·Nature Reviews. Rheumatology·Mario M ZaissFrancesco Ciccia
Nov 29, 2020·Current Opinion in Biotechnology·Seo-Young ParkArul Jayaraman
May 1, 2021·International Journal of Environmental Research and Public Health·Felipe Papa PellizoniGislane Lelis Vilela de Oliveira
May 1, 2021·Journal of Personalized Medicine·Nadji Hannachi, Laurence Camoin-Jau
Apr 26, 2020·Annals of the Rheumatic Diseases·Julia ManassonJose U Scher
Jul 6, 2021·Frontiers in Physiology·Xiaohua GuiMing D Li
Jun 29, 2021·Journal of Microbiology and Biotechnology·Xiaohui ZhongXue Chen
Aug 8, 2021·Journal of Clinical Medicine·Giuseppe ScaliseFrancesco Ciccia
Aug 18, 2021·Metabolomics : Official Journal of the Metabolomic Society·Jessica D Murillo-SaichMonica Guma

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Methods Mentioned

BETA
nuclear magnetic resonance
hormone replacement medications
16S-seq

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