Pharmacoprophylaxis of alcohol dependence: Review and update Part I: Pharmacology.

Indian Journal of Psychiatry
Sandeep GroverDebasish Basu

Abstract

Alcohol dependence is a major problem in India. The pharmacological armamentarium for relapse prevention of alcohol has widened with the addition of new drugs. In this article, we review the pharmacology and efficacy of the four most important such drugs: disulfiram, naltrexone, acamprosate and topiramate. The first part of this two-part review series concerns the comparative pharmacology and the second part concerns the efficacy studies. Overall, all four of these drugs have modest but clinically significant usefulness as pharmacoprophylactic agents for relapse prevention or minimization of alcohol dependence. Combinations might be helpful, especially for naltrexone and acamprosate. The issue of supervision and compliance remains important, especially for such drugs as disulfiram and naltrexone. Topiramate is a promising new agent and requires further study. Disulfiram, while very effective in compliant patients, presents challenges in terms of patient selection and side effects. For patients with hepatic impairment, acamprosate is a good choice.

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Citations

Oct 14, 2009·Indian Journal of Psychiatry·T S Sathyanarayana Rao, M N Anil Kumar
Jan 1, 2010·Indian Journal of Psychiatry·Charles Pinto
Jan 1, 2010·Indian Journal of Psychiatry·Pratima MurthyVivek Benegal
Mar 25, 2011·Indian Journal of Psychiatry·Princy Louis Palatty, Elroy Saldanha
Sep 21, 2013·Indian Journal of Psychological Medicine·Ranganath R Kulkarni, Bhavya K Bairy
Dec 15, 2015·Indian Journal of Psychological Medicine·Ranganath Ramarao Kulkarni, Bhavya K Bairy
Aug 16, 2016·Journal of Clinical Psychopharmacology·Jaiganesh Selvapandian ThamizhRavi Philip Rajkumar
Aug 17, 2011·International Journal of Environmental Research and Public Health·Angelo Giovanni Icro MaremmaniIcro Maremmani
Jan 8, 2019·Korean journal of family medicine·Habib Erensoy, Ahmet Emre Sargin
Nov 20, 2016·Neurodegenerative Disease Management·Victoria HayesBrian Draper
May 18, 2021·Journal of Clinical and Experimental Hepatology·Narendra S ChoudharyArvinder S Soin

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Methods Mentioned

BETA
pharmacotherapy
sedation

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