Pharmacoresistance and expression of multidrug transporter P-glycoprotein in kindled rats

Neuroreport
Heidrun PotschkaWolfgang Löscher

Abstract

Multidrug transporter over-expression is considered to limit access of antiepileptic drugs to the epileptic focus region and to be one cause of intractable epilepsy. To reach further proof for this multidrug transporter hypothesis, we compared P-glycoprotein expression rates in subgroups of Wistar rats which are sensitive or resistant to the anticonvulsant effect of the antiepileptic drug phenytoin in the amygdala-kindling model of temporal lobe epilepsy. In the electrode-implanted amygdala of phenytoin-resistant rats, the area labelled for P-glycoprotein was more than twice as large than that in phenytoin-sensitive rats. The data indicate that P-glycoprotein expression levels in the kindled focus have a critical impact on the anticonvulsant response to antiepileptic drugs.

References

Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Apr 20, 2000·Epilepsy Research·W LöscherU Ebert
Mar 21, 2002·Epilepsia·H Matsuoka
Mar 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·Wolfgang Löscher, Heidrun Potschka
Apr 12, 2002·Seizure : the Journal of the British Epilepsy Association·Patrick Kwan, Martin J Brodie
Mar 29, 2003·The Journal of Pharmacology and Experimental Therapeutics·Heidrun PotschkaWolfgang Löscher
Apr 11, 2003·The New England Journal of Medicine·Asra SiddiquiSanjay M Sisodiya

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Citations

Mar 28, 2008·Current Oncology Reports·Jai GrewalArthur D Forman
Apr 10, 2009·Journal of Molecular Neuroscience : MN·Linyu TianDong Zhou
Jun 11, 2005·Epilepsia·Dieter Schmidt, Wolfgang Löscher
Feb 24, 2007·Epilepsia·Wolfgang Löscher
Sep 8, 2005·Epilepsy Currents·Wolfgang Löscher
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Wolfgang Löscher, Heidrun Potschka
May 18, 2010·Expert Review of Anticancer Therapy·Charles J Vecht, Erik B Wilms
Dec 27, 2011·Advanced Drug Delivery Reviews·Chunbo ZhangLarry Baum
Dec 6, 2011·Advanced Drug Delivery Reviews·Eleonora AronicaJan A Gorter
Jul 14, 2005·Progress in Neurobiology·Wolfgang Löscher, Heidrun Potschka
Apr 17, 2007·Lancet Neurology·Melanie S M van BreemenCharles J Vecht
Jul 25, 2019·Annals of Neurology·Cenglin XuZhong Chen
Nov 28, 2017·Journal of Neuro-oncology·Andrés F CardonaZyanya Lucia Zatarain-Barrón
Jul 22, 2017·Frontiers in Neurology·Fei TangBjörn Bauer
Jun 6, 2009·The Journal of Pharmacology and Experimental Therapeutics·Anton PekcecHeidrun Potschka
Mar 8, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gurpreet Kaur GrewalRitushree Kukreti
Jun 17, 2020·Pharmacological Reviews·Wolfgang LöscherAnnamaria Vezzani
Dec 2, 2020·Pharmaceutics·Manuela Gernert, Malte Feja

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