Pharmacotherapeutic options for the management of human polyomaviruses

Advances in Experimental Medicine and Biology
Julie RoskopfNasimul Ahsan

Abstract

Polyomaviruses [BK virus (BKV), JC virus (JCV) and simian virus 40 (SV40)] have been known to be associated with diseases in humans for over thirty years. BKV-associated nephropathy and JCV-induced progressive multifocal leukoencephalopathy (PML) were for many years rare diseases occurring only in patients with underlying severe impaired immunity. Over the past decade, the use of more potent immunosuppression (IS) in transplantation, and the Acquired Immune Deficiency Syndrome (AIDS) epidemic, have coincided with a significant increase in the prevalence of these viral complications. Prophylactic and therapeutic interventions for human polyomavirus diseases are limited by our current understanding of polyomaviral pathogenesis. Clinical trials are limited by small numbers of patients affected with clinically significant diseases, lack of defined risk factors and disease definitions, no proven effective treatment and the overall significant morbidity and mortality associated with these diseases. This chapter will focus on a review of the current and future research related to therapeutic targets and interventions for polyomavirus-associated diseases.

Citations

May 29, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Steven GabardiAnil Chandraker
May 20, 2015·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S GabardiC S Tan
Mar 2, 2012·Clinical Pharmacology and Therapeutics·M Vinhas de SouzaG Dal Pan
Jul 29, 2008·Neurologic Clinics·Thomas Weber

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