PMID: 11898553Mar 20, 2002Paper

Pharmacotheraphy for Alzheimer's disease

Current Neurology and Neuroscience Reports
David Knopman

Abstract

In the past 2 years, substantive advances in therapy for Alzheimer's disease (AD) have occurred. The nature of the effects of cholinesterase inhibitors has been refined with the publication of several studies that have examined different aspects of the symptomatology of AD. Breakthroughs in the basic science of Alzheimer's disease have led to new insights into potential therapeutic strategies targeted at the secretases involved in the metabolism of the Alzheimer precursor protein. An immunization approach, in which the beta-amyloid protein itself was used as the immunizing agent, has also been presented and independently validated. Other areas of investigation with disappointing results, such as estrogen replacement therapy, anti-inflammatory approaches, and several other therapeutic agents, are also reviewed.

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Citations

Sep 15, 2005·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·J WiltfangK Blennow
Feb 14, 2008·Proteomics·Piotr Lewczuk, Jens Wiltfang
Aug 18, 2018·Frontiers in Behavioral Neuroscience·Barbara BudzynskaAnna Boguszewska-Czubara
Dec 18, 2003·British Journal of Clinical Pharmacology·G A FordS H D Jackson

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