PMID: 11927781Apr 3, 2002Paper

Pharmacotherapy in congestive heart failure: diuretic resistance and strategies to overcome resistance in patients with congestive heart failure

Congestive Heart Failure
Susan L RavnanPrakash C Deedwania

Abstract

Congestive heart failure is a complex clinical hemodynamic disorder characterized by chronic and progressive pump failure and fluid accumulation. Although the overall impact of diuretic therapy on congestive heart failure mortality remains unknown, diuretics remain a vital component of symptomatic congestive heart failure management. Over time, sodium and water excretion are equalized before adequate fluid elimination occurs. This phenomenon is thought to occur in one out of three patients with congestive heart failure on diuretic therapy and is termed diuretic resistance. In congestive heart failure, both pharmacokinetic and pharmacodynamic alterations are thought to be responsible for diuretic resistance. Due to disease chronicity, symptomatic management is vital to improved quality of life and enhancing diuretic response is therefore pivotal.

References

Aug 12, 1978·British Medical Journal·D H LawsonW J Tillstone
Apr 1, 1992·Postgraduate Medical Journal·J W Gray, S J Pedler
Aug 1, 1991·The New England Journal of Medicine·UNKNOWN SOLVD InvestigatorsJay N Cohn
May 24, 1986·British Medical Journal·H Ring-LarsenN J Christensen
Aug 1, 1986·Clinical Pharmacology and Therapeutics·D C BraterD Brown-Cartwright
May 1, 1974·American Heart Journal·J BeregovichB Levitt
Aug 1, 1984·Kidney International·D C BraterS Anderson
Aug 1, 1982·Kidney International·D C BraterP Chennavasin
Aug 1, 1980·Clinical Pharmacology and Therapeutics·D C BraterR Seiwell
Feb 1, 1995·Journal of Internal Medicine·C HallerW Kübler
Jul 1, 1996·Journal of the American Society of Nephrology : JASN·D L VargoS K Swan
Oct 1, 1995·The Annals of Pharmacotherapy·S L YeltonK M Murray
Mar 1, 1997·Journal of Cardiovascular Pharmacology·H Knauf, E Mutschler
May 1, 1997·The Medical Clinics of North America·R T Morrison
Aug 1, 1997·Clinical Pharmacology and Therapeutics·J A FergusonD C Brater
May 13, 1999·The American Journal of Medicine·B K KrämerG A Riegger
Sep 29, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R MinutoloD Russo
Jan 5, 2002·The New England Journal of Medicine·J N CohnUNKNOWN Valsartan Heart Failure Trial Investigators
Feb 7, 2002·JAMA : the Journal of the American Medical Association·Anju NohriaLynne Warner Stevenson

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Citations

Feb 28, 2008·Current Opinion in Cardiology·Nadine GauthierHaissam Haddad
Apr 9, 2016·Indian Heart Journal·Ali Vazir, Martin R Cowie
Oct 22, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Benjamin J FredaGregory L Braden
Nov 23, 2006·The American Journal of Medicine·James A HillWilliam T Abraham
Nov 19, 2014·Clinical Cardiology·Elias B Hanna, Eliana Hanna Deschamps
Feb 2, 2011·Journal of Pharmacological Sciences·Promsuk JutabhaHiroyuki Sakurai
Sep 12, 2016·Anatomical Science International·Naoyuki OtaniNaohiko Anzai
Oct 25, 2016·International Journal of Cardiology·Mitja LainscakGiuseppe M C Rosano
Jul 22, 2017·Therapeutic Advances in Cardiovascular Disease·Niel ShahTimothy J Vittorio
Jun 6, 2020·Pharmacology Research & Perspectives·Xiandu LuoYanqing Wu
Jan 1, 2011·Journal of Pharmacological Sciences·Promsuk JutabhaHiroyuki Sakurai
Dec 28, 2019·Journal of Cardiothoracic and Vascular Anesthesia·Archit SharmaHarish Ramakrishna

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