Pharmacotherapy in Critically Ill Children: A Retrospective Review of 17,199 Admissions

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Melany GaetaniChristopher Parshuram

Abstract

Despite the ubiquitous role of pharmacotherapy in the care of critically ill children, descriptions of the extent of pharmacotherapy in critical illness are limited. Greater understanding of drug therapy can help identify clinically important associations and assist in the prioritization of efforts to address knowledge gaps. The objectives of this study were to describe the diversity, volume, and patterns of pharmacotherapy in critically ill children. A retrospective cohort study was performed with patient admissions to the ICU between July 31, 2006, and July 31, 2015. The study took place at a single, free-standing, pediatric, quaternary center. Eligible patient admissions were admitted to the ICU for more than 6 hours and received one or more drug administration. There were a total 17,482 patient-admissions and after exclusion of 283 admissions (2%) with no documented enteral or parenteral drug administration, 17,199 eligible admissions were studied. None. The 17,199 eligible admissions were admitted to the ICU for 2,208,475 hours and received 515 different drugs. The 1,954,171 administrations were 894,709 (45%) enteral administrations, 998,490 (51%) IV injections and 60,972 (3%) infusions. Infusions were administered for 4,4...Continue Reading

References

Apr 1, 1978·Intensive Care Medicine·N Buchanan, R D Cane
Aug 1, 1992·Journal of Paediatrics and Child Health·L A Bordun, W Butt
Apr 1, 1981·Intensive Care Medicine·M L FarinaG Tognoni
May 10, 2001·JAMA : the Journal of the American Medical Association·R KaushalD A Goldmann
Jan 16, 2002·JAMA : the Journal of the American Medical Association·Andrés EstebanMechanical Ventilation International Study Group
Feb 21, 2003·The New England Journal of Medicine·Margaret S HerridgeCanadian Critical Care Trials Group
Feb 28, 2004·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Michael A CiminoChild Health Accountability Initiative
Feb 23, 2005·Archives of Disease in Childhood. Fetal and Neonatal Edition·R Van LitsenburgC S Parshuram
Mar 5, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Steven A ConradHeidi J Dalton
May 25, 2005·European Journal of Pediatrics·Chiara Pandolfini, Maurizio Bonati
Aug 3, 2006·Pediatrics·Jennifer LeJane Hodding
Sep 18, 2007·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Kristina Johnell, Inga Klarin
Jun 10, 2008·Journal of Critical Care·Orit Manor-ShulmanChristopher Parshuram
May 21, 2009·Critical Care Medicine·Frank W MolerPediatric Emergency Care Applied Research Network
Feb 6, 2010·Archives of Disease in Childhood·Maisoon Abdullah GhalebIan Chi Kei Wong
Mar 17, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Miriam SantschiEuropean Society of Pediatric and Neonatal Intensive Care (ESPNIC)
Jan 26, 2011·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Navjeet UppalChristopher Parshuram
Feb 25, 2011·Journal of Cardiovascular Pharmacology·Kevin WattMichael Cohen-Wolkowiez
Sep 7, 2011·Archives of Pediatrics & Adolescent Medicine·Chris FeudtnerTalene A Metjian
Oct 14, 2011·Epilepsia·Claude G WasterlainJerome Niquet
Apr 5, 2012·Clinical Pharmacology and Therapeutics·E Kimland, V Odlind
Aug 24, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Nicole A RizkallaAthena F Zuppa
Jan 21, 2015·JAMA : the Journal of the American Medical Association·Martha A Q CurleyRESTORE Study Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators Network
Dec 18, 2015·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Corrine R BalitPeter N Cox
Mar 10, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Dingwei DaiChris Feudtner
May 5, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Varsha Bhatt-Mehta
Aug 16, 2016·The Journal of Pediatrics·Kanecia O ZimmermanChristoph P Hornik
Aug 23, 2016·The Journal of Pharmacy and Pharmacology·Manuel A BaarslagDick Tibboel

Methods Mentioned

BETA
pharmacotherapy

Related Concepts

Critical Illness
Pharmacotherapy
Combination Drug Therapy
Pharmaceutical Preparations
Intensive Care Unit
Patient Admission
Retrospective Studies
Hospital Admission
Illness (Finding)
Standing Position

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.

Related Papers

Critical Care and Resuscitation : Journal of the Australasian Academy of Critical Care Medicine
Shyamala Sriram, Megan S Robertson
JPEN. Journal of Parenteral and Enteral Nutrition
Mitchell S FarberMargaret Korn
Zeitschrift für Gastroenterologie
R W Luther
© 2021 Meta ULC. All rights reserved