PMID: 9543650Apr 17, 1998Paper

Pharmacotherapy of cerebral ischemia in cocaine dependence

Drug and Alcohol Dependence
T R Kosten

Abstract

This paper will examine how cerebral perfusion deficits in cocaine abusers may be a target for pharmacotherapy. The review covers five areas: (1) cerebral ischemia and neuropsychological impairment in cocaine abusers, (2) neuroimaging evidence for cerebral perfusion defects in cocaine abusers, (3) mechanisms for cocaine induced cerebral thrombosis, (4) neurotoxicity from cerebral ischemia and excitatory amino acids, (5) glutamate antagonists as potential treatment agents for cocaine induced neurotoxicity. Several pharmacotherapies are suggested including antiplatelet agents and excitatory amino acid (EAA) antagonists such as lamotrigine. Clinical trials in cocaine abusers with cerebral perfusion defects are indicated and EAA antagonists hold promise as they are developed for stroke treatment.

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Citations

Jan 7, 2004·Biological Psychiatry·Thomas R KostenHenry M Rinder
Nov 7, 2000·Psychiatry Research·N BoutrosT Kosten
Aug 9, 2002·Drug and Alcohol Dependence·P C Gottschalk, Thomas R Kosten
Aug 21, 2003·Drug and Alcohol Dependence·Thomas R KostenHenry M Rinder
Feb 13, 2001·Free Radical Biology & Medicine·L Venturini, S B Sparber
Jun 7, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·E Sherwood BrownThomas J Carmody
Feb 4, 2003·Journal of Psychoactive Drugs·Robert MalcolmPerry V Halushka
Jun 24, 2008·Science & Practice Perspectives·Thomas R Kosten, Tony P George
Jan 18, 2005·CNS Drugs·Mehmet Sofuoglu, Thomas R Kosten
Apr 28, 2009·Journal of Substance Abuse Treatment·Travis H TurnerRobert Malcolm
Oct 2, 2007·Neurochemistry International·Sushil Sharma, Manuchair Ebadi
Apr 21, 2004·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Jeffrey N BrowndykeThomas R Kosten
Oct 13, 2006·Drug and Alcohol Dependence·John Monterosso, George Ainslie
Jun 21, 2014·The American Journal of Drug and Alcohol Abuse·Nicholas D Wignall, E Sherwood Brown
Aug 1, 2014·Neuropharmacology·Scott E Lukas
Dec 17, 2009·Substance Use & Misuse·Lúcio Garcia De OliveiraSolange Aparecida Nappo
Jul 26, 2007·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Felix Henrique Paim KesslerFlavio Pechansky
Jul 10, 2002·Stroke; a Journal of Cerebral Circulation·Bernard Noël
Dec 21, 2000·Current Psychiatry Reports·G O'Leary, R D Weiss
Mar 5, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mary Irene Mendoza-BaumgartSheldon B Sparber

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