Pharmacotherapy of cervical cancer

Expert Opinion on Pharmacotherapy
Francesco LeggeGabriella Ferrandina

Abstract

Cervical cancer (CC) remains an important health problem. It is the second most frequent malignancy in women worldwide, with one-third of patients dying from pharmacoresistant disease. We reviewed pharmacotherapy approaches in the medical and multidisciplinary management of CC and conducted a systematic search of Pubmed for clinical trials, reviews and meta-analysis published in the last 20 years. Abstracts of the American Society of Clinical Oncology, European Society of Gynecological Oncology and International Gynecologic Cancer Society were also searched, together with the US National Institutes of Health clinical trial database. The state-of-the art of cytotoxic and biologically targeted therapies in early, locally advanced and metastatic/recurrent CC is discussed. Until recently, the role of pharmacotherapy in CC was restricted to palliation of advanced/metastatic or recurrent disease. During the past two decades, this reluctant attitude towards chemotherapy has been modified after a series of randomized trials demonstrated its beneficial contribution as an adjunct to radiotherapy or surgery in early and locally advanced CC. Moreover, new combinations of cytotoxics, together with novel molecular target agents, open new per...Continue Reading

References

Mar 1, 1989·Journal of the National Cancer Institute·E J BuxtonD M Luesley
Aug 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P BonomiF J Major
Jan 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A M MuradJ C Ribalta
Mar 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·D ChassagneG Michel
Mar 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W P McGuireG Photopulos
Jan 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G A OmuraB Anderson
Feb 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C F VerschraegenJ J Kavanagh
Mar 21, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M MorrisD M Gershenson
Jun 26, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P Benedetti-PaniciS Mancuso
Apr 15, 1999·The New England Journal of Medicine·P G RoseS Insalaco
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L C WongD T Choy
Dec 10, 1999·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G ZanettaC Mangioni
Mar 31, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C LhomméS Pecorelli
Apr 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W A PetersD S Alberts
Apr 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T C ChangY K Soong
Mar 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J P CurtinR D Alvarez
Jun 12, 2001·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A Dueñas-GonzalezJ De la Garza
Jan 5, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pierluigi Benedetti-PaniciFabio Landoni
Mar 29, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey D BlossJo Benda
Mar 26, 2003·International Journal of Radiation Oncology, Biology, Physics·Vicharn LorvidhayaEkachai Visetsiri
Nov 7, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·UNKNOWN Neoadjuvant Chemotherapy for Locally Advanced Cervical Cancer Meta-analysis Collaboration
Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patricia J EifelDavid G Mutch
Jun 26, 2004·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·D LerougeM Jamali
Jul 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David H MooreThomas F Rocereto
May 14, 2005·Critical Reviews in Oncology/hematology·Krystyna Serkies, Jacek Jassem
May 25, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bradley J MonkUNKNOWN Gynecologic Oncology Group Study

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