Pharmacotherapy of premature ejaculation: a systematic review and network meta-analysis

International Urology and Nephrology
Zhongyu JianKunjie Wang

Abstract

The purpose of the study was to conduct a systematic evaluation of the different general prescribed drugs for premature ejaculation (PE). A systematic literature search of MEDLINE, Cochrane Central Register of Controlled Trials, and Web of Science for Systematic Reviews was performed on 1 March 2018. Intravaginal ejaculation latency time (IELT) was the main outcome. Analysis was performed under multivariate random-effects network model and efficacies of drugs were ranked with surface under the cumulative ranking (SUCRA) probabilities. A total of 48 studies were reviewed and 40 of them were further enrolled into network meta-analysis. The majority of RCTs were of unclear methodological quality. Pooled evidence suggested that topical anaesthetic creams (TAs), tramadol, selective serotonin reuptake inhibitors (SSRIs), and phosphodiesterase type 5 inhibitors (PDE5is) are more effective at prolonging IELT comparing with placebo. TAs (90%) on demand (OD) and PDE5is plus SSRI (89.8%) had the highest SUCRA, which meant the most probable to be the most effective intervention. We recommend the initial use of dapoxetine 30 mg OD for PE because it has been tested in largest and better designed clinical trials rather than it is more effecti...Continue Reading

References

Sep 1, 1994·The American Journal of Psychiatry·M D WaldingerA H Zwinderman
Feb 6, 1999·International Urology and Nephrology·H BiriI Bozkirli
Dec 11, 2002·Andrologia·M K AtikelerF A Senol
Dec 21, 2002·International Journal of Impotence Research·M AtmacaA Semercioz
Sep 25, 2003·Journal of Sex & Marital Therapy·T SymondsS Althof
Jan 18, 2006·International Journal of STD & AIDS·Daniel RichardsonUNKNOWN BASHH Special Interest Group for Sexual Dysfunction
Jan 18, 2006·Journal of Clinical Psychopharmacology·Mohammad Reza Safarinejad, Seyyed Yoosof Hosseini
Jan 21, 2006·The Journal of Sexual Medicine·Chris G McMahonMitra Boolell
Jan 25, 2006·The Journal of Sexual Medicine·David RowlandKai-Fai Ho
Feb 14, 2007·The Journal of Urology·David L RowlandDennis D Gagnon
Mar 17, 2007·The Journal of Sexual Medicine·Emad A SalemMario A Cleves
May 2, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Wei-Fu WangDavid J Ralph
Jul 14, 2007·Urologia Internationalis·Mohammad M Hosseini, Hooman Yarmohammadi
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Nov 3, 2009·The Journal of Sexual Medicine·Chris McMahonUNKNOWN Dapoxetine 3003 Study Investigators
Apr 7, 2010·The Journal of Sexual Medicine·Moheiddin AlghobaryMostafa Amr
Nov 18, 2011·Urology·Mehmet KaynarTalat Yurdakul
Oct 30, 2012·Asian Journal of Andrology·Bayoumy I Eassa, Mohamed A El-Shazly
May 16, 2013·BMJ : British Medical Journal·Edward J MillsJohn P A Ioannidis
Nov 20, 2013·Indian Journal of Psychological Medicine·Amil H Khan, Deepa Rasaily
Jan 11, 2016·European Urology·Fabio CastiglioneFrancois Giuliano
Mar 17, 2016·Nephro-urology Monthly·Emadouddin Moudi, Ali Akbar Kasaeeyan

❮ Previous
Next ❯

Citations

Dec 7, 2019·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Soheila SiroosbakhtBijan Rezakhaniha
Mar 22, 2021·The Cochrane Database of Systematic Reviews·Niranjan J SathianathenPhilipp Dahm
Jun 30, 2021·European Urology·Andrea SaloniaUNKNOWN EAU Working Group on Male Sexual and Reproductive Health

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.