Pharmacovigilance from social media: An improved random subspace method for identifying adverse drug events

International Journal of Medical Informatics
Jing Liu, Gang Wang

Abstract

Recent advances in Web 2.0 technologies have seen significant strides towards utilizing patient-generated content for pharmacovigilance. Social media-based pharmacovigilance has great potential to augment current efforts and provide regulatory authorities with valuable decision aids. Among various pharmacovigilance activities, identifying adverse drug events (ADEs) is very important for patient safety. However, in health-related discussion forums, ADEs may confound with drug indications and beneficial effects, etc. Therefore, the focus of this study is to develop a strategy to identify ADEs from other semantic types, and meanwhile to determine the drug that an ADE is associated with. In this study, two groups of features, i.e., shallow linguistic features and semantic features, are explored. Moreover, motivated and inspired by the characteristics of explored two feature categories for social media-based ADE identification, an improved random subspace method, called Stratified Sampling-based Random Subspace (SSRS), is proposed. Unlike conventional random subspace method that applies random sampling for subspace selection, SSRS adopts stratified sampling-based subspace selection strategy. A case study on heart disease discussion ...Continue Reading

Citations

Jan 15, 2021·Biomaterials Science·Farooq AhmadTahir Muhmood
Aug 7, 2019·Trends in Pharmacological Sciences·Anna O BasileNicholas P Tatonetti
Feb 6, 2019·The Journal of Allergy and Clinical Immunology·Kimberly G BlumenthalAidan A Long

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.