Pharmacovigilance.

British Journal of Clinical Pharmacology
I Ralph Edwards

Abstract

Adverse drug reactions are the fifth most frequent cause of deaths in developed countries, effectively a global epidemic. However, progress in ameliorating the problem has been slow. Pharmacovigilance currently operates without clear objectives in relation to individual decisions, with no protocol (although risk management plans are a great step forward), with obscure materials and methods used for making decisions, with very limited reasoning and discussion, and little or no follow up and audit of the results. Problems include under-reporting, poor quality reports, underuse of the latest communications technology and suboptimal individual feedback to reporters. Assessment of causality is poor, impeding decision-making. After signal detection, more active measures to assess the risk to public health are needed. Other essential factors include precision about the ways in which data are prepared and transformed into databases, the recognition of secondary effects, which may be more obvious than the primary effect, but not so easy to link causally, and cognisance of all kinds of interactions. Areas that should be developed include pharmacoepidemiology, knowledge finding (through data mining), and communication and systems technolo...Continue Reading

References

Apr 29, 1998·JAMA : the Journal of the American Medical Association·J LazarouP N Corey
Mar 6, 2003·Pharmacoepidemiology and Drug Safety·Patrick C Waller, Stephen J W Evans
Jan 1, 1965·Journal of Chronic Diseases·D J FINNEY
Nov 25, 2003·BMJ : British Medical Journal·J K Aronson, R E Ferner
Jul 3, 2004·BMJ : British Medical Journal·Munir PirmohamedAlasdair M Breckenridge
Feb 25, 2009·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Jeffrey K AronsonRobin E Ferner
May 7, 2009·Journal of the Royal Society of Medicine·Jeremy HowickJeffrey K Aronson
Dec 17, 2009·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Robin E Ferner, Jeffrey K Aronson
Aug 12, 2010·JAMA : the Journal of the American Medical Association·Chris R CardwellLiam J Murray
Sep 4, 2010·BMJ : British Medical Journal·Diane K Wysowski

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Citations

Apr 26, 2013·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Pornwalai BoonmuangPairin Supsongserm
Nov 20, 2014·European Journal of Clinical Pharmacology·V PaulyJ Micallef
Feb 7, 2017·PloS One·Fabiana Rossi VaralloPatricia de Carvalho Mastroianni
Aug 30, 2017·Veterinary Record Open·Nancy De BriyneDeclan O'Rourke
Dec 7, 2013·Journal of Clinical Pharmacy and Therapeutics·M Abou TaamH Bagheri
Oct 12, 2018·Revista da Escola de Enfermagem da U S P·Fabiana Rossi VaralloPatricia de Carvalho Mastroianni
Oct 24, 2017·Journal of the National Cancer Institute·Sean KhozinRichard Pazdur
Nov 6, 2018·Thérapie·Jean-Louis MontastrucAgnès Sommet

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