PHARMacy-based interdisciplinary program for patients with Chronic Heart Failure (PHARM-CHF): rationale and design of a randomized controlled trial, and results of the pilot study

European Journal of Heart Failure
Ulrich LaufsMartin Schulz

Abstract

We report the rationale and design of a community PHARMacy-based prospective randomized controlled interdisciplinary study for ambulatory patients with Chronic Heart Failure (PHARM-CHF) and results of its pilot study. The pilot study randomized 50 patients to a pharmacy-based intervention or usual care for 12 months. It demonstrated the feasibility of the design and showed reduced systolic blood pressure in the intervention group as indicator for improved medication adherence. The main study will randomize patients ≥60 years on stable pharmacotherapy including at least one diuretic and a history of heart failure hospitalization within 12 months. The intervention group will receive a medication review at baseline followed by regular dose dispensing of the medication, counselling regarding medication use and symptoms of heart failure. The control patients are unknown to the pharmacy and receive usual care. The primary efficacy endpoint is medication adherence, pre-specified as a significant difference of the proportion of days covered between the intervention and control group within 365 days following randomization using pharmacy claims data for three CHF medications (angiotensin-converting enzyme inhibitors or angiotensin recep...Continue Reading

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Citations

May 18, 2019·European Journal of Heart Failure·Aldo P Maggioni
May 28, 2019·European Journal of Heart Failure·Martin SchulzUNKNOWN PHARM-CHF Investigators
May 10, 2020·The Cochrane Database of Systematic Reviews·Amanda J CrossJohnson George
Sep 12, 2019·Current Treatment Options in Cardiovascular Medicine·Lucianne M WestKathleen D Faulkenberg
Jan 31, 2020·ESC Heart Failure·Daniela TomasoniMarco Metra
Nov 17, 2020·Journal of Interprofessional Care·Kanayuki KitaharaTadanori Sasaki

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