PharmGKB summary: clobazam pathway, pharmacokinetics

Aug 30, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·William M Pardridge

Clobazam: a newly approved but well-established drug for the treatment of intractable epilepsy syndromes

Nov 1, 2012·Journal of Child Neurology·James W Wheless, Stephanie J Phelps

Clobazam therapeutic drug monitoring: a comprehensive review of the literature with proposals to improve future studies

Jan 16, 2013·Therapeutic Drug Monitoring·Jose de LeonFrancisco J Diaz

Influence of CYP2C19 polymorphism and concomitant antiepileptic drugs on serum clobazam and N-desmethyl clobazam concentrations in patients with epilepsy

May 15, 2013·Therapeutic Drug Monitoring·Yoshiaki YamamotoYoshiyuki Kagawa

Effects of CYP2C19 and P450 oxidoreductase polymorphisms on the population pharmacokinetics of clobazam and N-desmethylclobazam in japanese patients with epilepsy

Dec 19, 2013·Therapeutic Drug Monitoring·Junji SaruwatariKazuko Nakagawa

Clobazam and its active metabolite N-desmethylclobazam display significantly greater affinities for α₂- versus α₁-GABA(A)-receptor complexes

Feb 18, 2014·PloS One·Henrik Sindal JensenBjarke Ebert

Interaction between sulthiame and clobazam: sulthiame inhibits the metabolism of clobazam, possibly via an action on CYP2C19

Apr 20, 2014·Epilepsy & Behavior : E&B·Yoshiaki YamamotoYushi Inoue

Modified Atkins diet may reduce serum concentrations of antiepileptic drugs

Oct 15, 2014·Acta Neurologica Scandinavica·M KvernelandK O Nakken

Effect of CYP2C19 polymorphisms on the clinical outcome of low-dose clobazam therapy in Japanese patients with epilepsy

Oct 18, 2014·European Journal of Clinical Pharmacology·Sachiyo HashiKazuo Matsubara

Study of the Interaction of 1,4- and 1,5-Benzodiazepines with GABAA Receptors of Rat Cerebellum Granule Cells in Culture

Jan 27, 2015·Journal of Molecular Neuroscience : MN·Periklis NikasMauro Robello

Toxic epidermal necrolysis triggered by clobazam: a case report in a 13-year-old girl

Feb 19, 2015·Pediatric Dermatology·Chuong D DangEstelle C Kahn

Functional characterization of the 1,5-benzodiazepine clobazam and its major active metabolite N-desmethylclobazam at human GABA(A) receptors expressed in Xenopus laevis oocytes

Mar 24, 2015·PloS One·Harriet HammerAnders A Jensen

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Citations

An evaluation of clobazam tablets and film (AQST-120) for the treatment of Lennox-Gastaut syndrome

Aug 3, 2019·Expert Opinion on Pharmacotherapy·Frank M C Besag, Michael J Vasey

Dynamic Effects of CYP2D6 Genetic Variants in a Set of Poor Metaboliser Patients with Infiltrating Ductal Cancer Under Treatment with Tamoxifen

Feb 23, 2019·Scientific Reports·Yeimy Viviana Ariza MárquezJuvenal Yosa Reyes

Initiation of Transdermal Fentanyl Among US Commercially Insured Patients Between 2007 and 2015.

May 8, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Ryan C CostantinoJulia F Slejko

Potential drug-drug interactions associated with drugs currently proposed for COVID-19 treatment in patients receiving other treatments

Jul 1, 2020·Fundamental & Clinical Pharmacology·Florian LemaitreUNKNOWN French Society of Pharmacology, Therapeutics (SFPT), the International Association of Therapeutic Drug Monitoring, Clinical

Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration.

Oct 25, 2020·International Journal of Molecular Sciences·Kristy R KutanziIgor Koturbash

Pharmacogenomic Biomarkers and Their Applications in Psychiatry.

Dec 4, 2020·Genes·Heejin Kam, Hotcherl Jeong

1,3-Diazepine: A privileged scaffold in medicinal chemistry.

Mar 2, 2021·Medicinal Research Reviews·Yohan MalkiNicolas Masurier

Super-Refractory Status Epilepticus: Prognosis and Recent Advances in Management.

Jul 6, 2021·Aging and Disease·Batool F KirmaniRobert J Delorenzo

The Essential Medicinal Chemistry of Cannabidiol (CBD).

Aug 18, 2020·Journal of Medicinal Chemistry·Kathryn M NelsonGuido F Pauli

[Analysis of the feasibility of a forensic chemical investigation in clobazam poisoning].

Feb 11, 2022·Sudebno-meditsinskaia ekspertiza·A A VolkovaS R Nevmyatova

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PharmGKB summary: clobazam pathway, pharmacokinetics

Abstract

References

Review of clinical studies on clobazam

Kinetics and metabolism of clobazam in animals and man

Pharmacokinetics of single and multiple doses of clobazam in humans

Antiepileptic properties of clobazam, a 1-5 benzodiazepine, in man

Effects of drugs on gamma-aminobutyric acid receptors, uptake, release and synthesis in vitro

Effects of age and antiepileptic drugs on plasma levels and kinetics of clobazam and N-desmethylclobazam

Pharmacokinetics of N-desmethylclobazam in healthy volunteers and patients with epilepsy

The effect of cimetidine on the single dose pharmacokinetics of oral clobazam and N-desmethylclobazam

N-desmethylclobazam: a possible alternative to clobazam in the treatment of refractory epilepsy?

Clobazam kinetics in the elderly

Clobazam as adjunctive treatment in refractory epilepsy

Single dose pharmacokinetic study of clobazam in normal volunteers and epileptic patients

Clobazam kinetics: intrasubject variability and effect of food on adsorption

Clobazam plasma concentrations: pharmacokinetic study in healthy volunteers and data in epileptic patients

Pharmacokinetics of a single oral dose of clobazam in patients with liver disease

Assembly and cell surface expression of heteromeric and homomeric gamma-aminobutyric acid type A receptors.

Effects of clobazam and its active metabolite on GABA-activated currents in rat cerebral neurons in culture

Mapping of the benzodiazepine recognition site on GABA(A) receptors

Evidence of polymorphic CYP2C19 involvement in the human metabolism of N-desmethylclobazam

Unusual side-effects due to clobazam: a case report with genetic study of CYP2C19

Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA(A) receptor gamma2 subunit

A major influence of CYP2C19 genotype on the steady-state concentration of N-desmethylclobazam

Simultaneous determination of clobazam and its major metabolite in human plasma by a rapid HPLC method

Pharmacological properties of GABAA receptors containing gamma1 subunits

Molecular regulation of glutamate and GABA transporter proteins by clobazam during epileptogenesis in Fe(+++)-induced epileptic rats

Eye rolling as a manifestation of clobazam toxicity in a child with epilepsy

Comparison and predictors of rash associated with 15 antiepileptic drugs

Efficacy of low-dose, add-on therapy of clobazam (CLB) is produced by its major metabolite, N-desmethyl-CLB

Stevens-Johnson syndrome and toxic epidermal necrolysis: assessment of medication risks with emphasis on recently marketed drugs. The EuroSCAR-study

Up-regulation of L-type high voltage-gated calcium channel subunits by sustained exposure to 1,4- and 1,5-benzodiazepines in cerebrocortical neurons

Impact of CYP2C19 polymorphisms on the efficacy of clobazam therapy

A case with Stevens Johnson syndrome triggered by combination of clobazam, lamotrigine, and valproic acid treatment

New 1,5-benzodiazepine compounds: activity at native GABA(A) receptors

Interactions between modulators of the GABA(A) receptor: Stiripentol and benzodiazepines

GABA(A) receptor physiology and its relationship to the mechanism of action of the 1,5-benzodiazepine clobazam

A case of a potential drug interaction between clobazam and etravirine-based antiretroviral therapy

Pharmacokinetic drug interactions between clobazam and drugs metabolized by cytochrome P450 isoenzymes

Benzodiazepines modulate GABAA receptors by regulating the preactivation step after GABA binding.

Drug transport across the blood-brain barrier.