Pharyngeal carcinoma and natural killer cell activity

American Journal of Surgery
S P SchantzO M Guillamondegui

Abstract

An evaluation of natural killer cell activity was performed in 42 patients with pharyngeal carcinoma. Compared with age- and sex-matched control subjects, the cancer patients expressed significantly lower cytotoxicity against K562 target cells (68 +/- 8 lytic units versus 99 +/- 8 lytic units, p less than 0.01), with 52 percent of the patients expressing deficient activity (below 1 standard deviation of the mean activity of the control population). The probability of deficient activity was greater in these patients than observed in patients with cancer of other head and neck sites. Although natural killer cell activity was lower in patients who drank alcohol or had nodal metastases, no single clinical factor was predictive of deficient cytotoxic response. Prospective longitudinal evaluation (mean = 12 months) of these pharyngeal cancer patients demonstrated that deficient natural killer cell activity measured before treatment identified a population with a significantly increased risk for the development of distant metastases. Distant metastases developed in 7 of 18 patients (39 percent) with deficient natural killer cell activity. In contrast, none of the 16 patients with normal natural killer cell function had evidence of dis...Continue Reading

References

May 1, 1979·The Journal of Experimental Medicine·N MinatoL M Reid
Nov 15, 1985·International Journal of Cancer. Journal International Du Cancer·E M de VilliersH zur Hausen
May 1, 1986·Archives of Otolaryngology--head & Neck Surgery·S P Schantz, L Poisson
Jan 1, 1974·Cancer·J C ProbertM A Bagshaw
Feb 1, 1982·Oral Surgery, Oral Medicine, and Oral Pathology·C Scully
Jan 15, 1984·Cancer·R J Papac
Feb 1, 1980·The Laryngoscope·M L DenningtonA D Meyers

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Citations

Apr 1, 1996·Cancer·J BrittendenO Eremin
Sep 28, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·William P AccomandoKarl T Kelsey
Oct 7, 2015·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Linda Le-WendlingXavier Capdevila
Nov 15, 2006·Immunological Reviews·Francois GhiringhelliLaurence Zitvogel
Mar 10, 2001·The American Journal of Gastroenterology·H TakeuchiK Sugimachi
Jun 15, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jennifer L SteelBrian I Carr
Oct 1, 1989·American Journal of Surgery·S P SchantzP G Sacks
Sep 14, 2018·Nature Reviews. Immunology·Laura ChiossoneEric Vivier
Jan 1, 1990·Fundamental & Clinical Pharmacology·P J Neveu, M Le Moal
Jul 15, 2004·Psychological Bulletin·Suzanne C Segerstrom, Gregory E Miller
Jan 1, 1993·The British Journal of Psychiatry : the Journal of Mental Science·M T Spurrell, F H Creed
Sep 4, 2019·The Journal of Clinical Investigation·Jonathan J HodginsMichele Ardolino
Nov 5, 2019·Journal of Cellular Biochemistry·S Haleh HosseiniHamed Mohammadi
Jan 2, 2019·Cancers·Seila Lorenzo-HerreroSegundo Gonzalez
Apr 15, 2021·Molecular Cancer Therapeutics·Robert W LentzWells A Messersmith

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