Pharyngeal colonization by Streptococcus pneumoniae in older children and adolescents in a geographical area characterized by relatively limited pneumococcal vaccination coverage

The Pediatric Infectious Disease Journal
Nicola PrincipiSusanna Esposito

Abstract

The aim of this study was to evaluate the relation between colonization and vaccination status with pneumococcal conjugate vaccine (PCV) in older children and adolescents living in an area characterized by relatively limited vaccination coverage. Oropharyngeal swabs were obtained from 2076 randomly selected healthy school-age children and adolescents, and the extracted genomic DNA was tested for Streptococcus pneumoniae by means of real-time polymerase chain reaction. All of the positive cases were subsequently serotyped, and the association between vaccination status with the heptavalent PCV (PCV7) and pneumococcal colonization was determined. S. pneumoniae was identified in the oropharyngeal swabs of 1201 subjects (57.9%), and its prevalence declined with age (74.9% in subjects aged <10 years, 51.8% in those aged 10-14 years and 32.7% in those aged ≥15 years; P < 0.001). There were more carriers of any pneumococcal serotype, any of the serotypes in PCV7, or any of the 6 additional serotypes in 13-valent PCV (PCV13) among the vaccinated than the unvaccinated subjects, but no association emerged after adjustment for age and other selected covariates. Sub-analyses by serotype and age groups revealed significant differences in th...Continue Reading

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Citations

Jan 14, 2016·Immunity & Ageing : I & a·Susanna EspositoNicola Principi
Sep 15, 2015·Human Vaccines & Immunotherapeutics·Nicola PrincipiUNKNOWN Italian Pneumococcal Study Group on Cancer
May 19, 2016·Future Microbiology·Rachid Y YahiaouiUNKNOWN APRES Study Team
Sep 24, 2015·International Journal of Immunopathology and Pharmacology·Susanna EspositoUNKNOWN Italian Pneumococcal Study Groups on Asthma, Cystic Fibrosis and Diabetes

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