Pharyngocutaneous fistula after salvage laryngectomy

Acta Oto-laryngologica
Nilda SüslüA Şefik Hoşal

Abstract

Preoperative chemoradiotherapy (CRT) was associated with a significantly higher rate of pharyngocutaneous fistula (PCF). PCF is the most frequent complication following total laryngectomy. Although organ-preserving radiotherapy (RT) or CRT offer good locoregional control, many patients still require salvage laryngectomy. The aim of this study was to evaluate the factors that predispose patients to PCF, with a focus on preoperative RT, induction chemotherapy (ICT), and CRT. This was a retrospective case series; 151 patients who underwent TL were reviewed. Preoperative RT, ICT, CRT, and some surgical parameters were analyzed as potential risk factors. The overall PCF rate was 13%. CRT was the only preoperative treatment that had a significant effect on PCF (35.3%, p = 0.004, odds ratio (OR) = 10.75). Surgery extended to the pharynx (p = 0.005, OR = 8.34) and vacuum drain duration (p = 0.012, OR = 5.16) were observed to be associated with PCF.

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Citations

Feb 26, 2016·Auris, Nasus, Larynx·Nilda Süslü, A Şefik Hoşal
Jun 7, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Z HasanF Riffat
Jun 26, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Cesare PiazzaPiero Nicolai
May 4, 2018·Laryngoscope Investigative Otolaryngology·Sarju S VasaniRobert Hodge
Nov 13, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Maohua WangChenjie Yu
Jun 28, 2021·American Journal of Otolaryngology·Bo HanJugao Fang
Jul 10, 2021·Frontiers in Oncology·Erika CrosettiGiovanni Succo

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