Abstract
This phase 1-2 trial assessed the efficacy and tolerability of an oral angiogenesis inhibitor-PTK787/ZK222584 (PTK)-in combination with intravenous doxorubicin for the treatment of advanced hepatocellular carcinoma (HCC) patients. In phase 1, advanced HCC patients received PTK at escalating doses together with doxorubicin 60 mg/m2 given as an intravenous bolus every 3 weeks to establish the maximum tolerated dose (MTD). Subsequently, in phase 2, all patients received the same regimen with oral PTK at the MTD dose every 3 weeks for a maximum of 6 cycles. Nine patients were recruited in phase 1, with the MTD established as 750 mg daily. Overall, 27 patients received the regimen with PTK at 750 mg daily. The median age was 52 years (range, 23-73 years), and 63 percent of patients were chronic hepatitis B carriers. Notably, the majority of patients had Child-Pugh B cirrhosis. The overall response rate was 26.0%, with all the responding patients having partial response. Another 20% of patients achieved stable disease for at least 12 weeks. The median progression-free survival was 5.4 months (range, 0.27-23.6 months), and overall survival was 7.3 months (range, 0.8-23.6 months). The commonest grade 3 or 4 nonhematological toxicities ...Continue Reading
References
Oct 15, 1990·Cancer·E C LaiJ Wong
Dec 15, 1985·Cancer·E SciarrinoL Pagliaro
Nov 1, 1995·Circulation·T AsaharaJ M Isner
Mar 14, 1996·The New England Journal of Medicine·V MazzaferroL Gennari
Jun 1, 1997·Human Pathology·N H ChowI J Su
Jan 1, 1997·British Journal of Cancer·L Griffiths, I J Stratford
Feb 12, 1998·Journal of Hepatology·H MiuraS Ohnishi
Oct 24, 1998·Annals of Internal Medicine·E MorM Schwartz
Feb 3, 2000·Journal of the National Cancer Institute·P TherasseS G Gwyther
Sep 5, 2001·Nature Medicine·R K Jain
Oct 11, 2001·Journal of Hepatology·J BruixUNKNOWN EASL Panel of Experts on HCC
Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·D M ParkinP Pisani
May 4, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anne L ThomasWilliam P Steward
May 4, 2005·Cancer Research·Yuqing LiuSheung Tat Fan
Mar 28, 2006·Cancer Letters·Roberta Pang, Ronnie T P Poon
Jul 11, 2006·World Journal of Gastroenterology : WJG·Zhong-Lin ZhangQuan Sun
Jan 16, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A L ThomasB Wiedenmann
Jul 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert G GishGerard T Kennealey
Sep 6, 2007·Cancer Metastasis Reviews·Richard J Epstein
Dec 22, 2007·Oncology·Roberta W C Pang, Ronnie T P Poon
Jun 21, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Abby B SiegelJonathan D Schwartz
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
Nov 26, 2008·World Journal of Gastroenterology : WJG·Thomas YauRonnie-T Poon
Dec 5, 2008·The New England Journal of Medicine·Giancarlo Spinzi, Silvia Paggi
Dec 20, 2008·The Lancet Oncology·Ann-Lii ChengZhongzhen Guan
Jan 6, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Thomas YauRonnie Tung Ping Poon
Jan 14, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Melanie B ThomasJames Abbruzzese
Citations
Jul 7, 2011·The Journal of Membrane Biology·Kim R Kampen
Aug 3, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·R A Pazo-CidP Martín-Duque
Mar 10, 2011·Nature Reviews. Clinical Oncology·Andrew X ZhuRakesh K Jain
Jan 21, 2012·Anti-cancer Drugs·Kim R Kampen
May 18, 2013·Current Opinion in Oncology·Jeroen DekervelChris Verslype
Apr 7, 2012·Journal of Oncology·Tam DuongMathias Francois
Mar 20, 2013·Annals of Surgical Oncology·Yoshiteru KatsuraHiroaki Nagano
Oct 12, 2013·World Journal of Gastroenterology : WJG·Jung Woo Shin, Young-Hwa Chung
Jul 12, 2012·Cancer Letters·Qi-Da HuTing-Bo Liang
Jun 30, 2011·Cancer·Julien EdelineJean-Luc Raoul
Nov 1, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Austin DuffyTim F Greten
Apr 18, 2013·Contemporary Clinical Trials·Dawn Qingqing ChongHan Chong Toh
Jun 4, 2019·Cells·Raffaele Di FranciaPaola Rossi
Aug 3, 2019·Cancers·Monica MossentaMichele Dal Bo
Nov 25, 2016·Frontiers in Pharmacology·Massimiliano BerrettaRaffaele Di Francia
Dec 25, 2015·Diseases·Khanh NguyenWeijing Sun
Apr 29, 2015·World Journal of Hepatology·Gan-Lu DengHong Shen
Apr 28, 2017·Molecular Medicine Reports·Ling-Jian KongJing Chen
Aug 15, 2018·Journal of Clinical Medicine·Meng-Yu WuChia-Jung Li