Phase 1 study of EUS-guided photodynamic therapy for locally advanced pancreatic cancer

Gastrointestinal Endoscopy
John M DeWittSafi Shahda

Abstract

Locally advanced pancreatic cancer (LAPC) has a poor prognosis. There are limited data describing the use of photodynamic therapy (PDT) for pancreatic cancer in humans. We hypothesized that EUS-guided PDT for LAPC is safe, technically feasible, and produces a dose- and time-dependent increasing degree of image-defined tumor necrosis. In a single-center, prospective, dose-escalation phase 1 study, patients with treatment-naïve LAPC received intravenous porfimer sodium (Concordia Laboratories Inc, St Michael, Barbados) followed 2 days later by EUS-PDT. EUS-PDT was performed by puncture with a 19-gauge needle and insertion of a 1.0-cm light diffuser (Pioneer Optics, Bloomfield, Conn) and illumination with a 630-nm light (Diomed Inc, Andover, Mass). A CT scan 18 days after PDT was done to assess for change in pancreatic necrosis. Nab-paclitaxel (125 mg/ m2 intravenously) and gemcitabine (1000 mg /m2 intravenously) were initiated 7 days after CT and given weekly for 3 of 4 weeks (1 cycle) until disease progression or unacceptable toxicity. Twelve patients (mean age, 67 ± 6 years; 8 male) with tumors (mean diameter, 45.2 ± 12.9 mm) in the head and/or neck (8) or body and/or tail (4) underwent EUS-PDT. Compared with baseline imaging, ...Continue Reading

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Citations

Aug 16, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Vladimíra PavlíčkováTomáš Ruml
Dec 31, 2019·Photochemistry and Photobiology·Tomonori Yano, Kenneth K Wang
Oct 5, 2020·Photochemistry and Photobiology·Vida KarimniaJonathan P Celli
Mar 30, 2020·Molecular Cancer Therapeutics·Sriram AnbilTayyaba Hasan
May 14, 2020·Journal of Photochemistry and Photobiology. B, Biology·Yujie ShenLeiming Xu
Sep 21, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·John M DeWittUNKNOWN AGA Center for GI Innovation and Technology
Nov 17, 2020·Frontiers in Bioengineering and Biotechnology·Nicholas Thomas BlumPeng Huang
Feb 21, 2021·Seminars in Oncology·Alberto LarghiGiampaolo Tortora
Feb 19, 2021·Photodiagnosis and Photodynamic Therapy·Pollyanna C V ConradoErika S Kioshima
Mar 2, 2021·Gastrointestinal Endoscopy·Yuri HanadaKenneth K Wang
May 10, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Marti BossMartin Gotthardt
Jan 15, 2022·Clinical Journal of Gastroenterology·Jahnvi Dhar, Jayanta Samanta

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