Abstract
Interactions between neural oscillations in the brain have been observed in many structures including the hippocampus, amygdala, motor cortex, and basal ganglia. In this study, one popular approach for quantifying oscillation interactions was considered: phase-amplitude coupling. The goals of the study were to use simulations to examine potential causes of elevated phase-amplitude coupling in parkinsonism, to compare simulated parkinsonian signals with recorded local field potentials from animal models of parkinsonism, to investigate possible relationships between increased bursting in parkinsonian single cells and elevated phase-amplitude coupling, and to uncover potential noise and artifact effects. First, a cell model that integrates incremental input currents and fires at realistic voltage thresholds was modified to allow control of stochastic parameters related to firing and burst rates. Next, the input currents and distribution of integration times were set to reproduce firing patterns consistent with those from parkinsonian subthalamic nucleus cells. Then, local field potentials were synthesized from the output of multiple simulated cells with varying degrees of synchronization and compared with subthalamic nucleus recor...Continue Reading
References
Jun 1, 1977·Electroencephalography and Clinical Neurophysiology·G Pfurtscheller, A Aranibar
Mar 15, 1988·Biological Psychiatry·M E WolfA D Mosnaim
Aug 1, 1994·Journal of Neurophysiology·H BergmanM R DeLong
Mar 20, 1998·British Journal of Anaesthesia·R J GajrajG N Kenny
Mar 3, 2004·Biophysical Journal·Claude BédardAlain Destexhe
Apr 29, 2004·Journal of Computational Neuroscience·Jonathan E Rubin, David Terman
Jul 11, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Plamen GatevThomas Wichmann
Sep 16, 2006·Science·R T CanoltyR T Knight
May 29, 2007·Trends in Neurosciences·Constance HammondPeter Brown
Jun 6, 2007·Trends in Cognitive Sciences·Ole Jensen, Laura L Colgin
Nov 26, 2009·Proceedings of the National Academy of Sciences of the United States of America·Adriano B L TortHoward Eichenbaum
May 14, 2010·Journal of Neurophysiology·Adriano B L TortNancy Kopell
May 14, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jon López-AzcárateManuel Alegre
Dec 15, 2010·Brain Research Bulletin·Béla WeissPéter Halász
Jan 6, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Roemer van der MeijEric Maris
Nov 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Laura D LewisPatrick L Purdon
Mar 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Coralie de HemptinnePhilip A Starr
May 17, 2013·Journal of Neurophysiology·Teresa H SandersThomas Wichmann
Dec 18, 2013·The European Journal of Neuroscience·Jonathan CannonNancy Kopell
Apr 18, 2014·Nature·Kei M IgarashiEdvard I Moser
Apr 29, 2014·Neurobiology of Disease·Annaelle DevergnasThomas Wichmann
Dec 20, 2014·The International Journal of Neuroscience·Aysegul GunduzMichael S Okun
Apr 14, 2015·Nature Neuroscience·Coralie de HemptinnePhilip A Starr
Apr 17, 2015·Journal of Neurophysiology·Allison T ConnollyMatthew D Johnson
Citations
Oct 17, 2017·Frontiers in Integrative Neuroscience·Teresa H Sanders
Jul 8, 2020·NeuroImage·Gabriel Gonzalez-EscamillaSergiu Groppa
Mar 13, 2021·Journal of Neural Engineering·AmirAli Farokhniaee, Madeleine Lowery