Phase-amplitude coupling and epileptogenesis in an animal model of mesial temporal lobe epilepsy

Neurobiology of Disease
Soheila SamieeSylvain Baillet

Abstract

Polyrhythmic coupling of oscillatory components in electrophysiological signals results from the interactions between neuronal sub-populations within and between cell assemblies. Since the mechanisms underlying epileptic disorders should affect such interactions, abnormal level of cross-frequency coupling is expected to provide a signal marker of epileptogenesis. We measured phase-amplitude coupling (PAC), a form of cross-frequency coupling between neural oscillations, in a rodent model of mesial temporal lobe epilepsy. Sprague-Dawley rats (n = 4, 250-300 g) were injected with pilocarpine (380 mg/kg, i.p) to induce a status epilepticus (SE) that was stopped after 1 h with diazepam (5 mg/kg, s.c.) and ketamine (50 mg/kg, s.c.). Control animals (n = 6) did not receive any injection or treatment. Three days after SE, all animals were implanted with bipolar electrodes in the hippocampal CA3 subfield, entorhinal cortex, dentate gyrus and subiculum. Continuous video/EEG recordings were performed 24/7 at a sampling rate of 2 kHz, over 15 consecutive days. Pilocarpine-treated animals showed interictal spikes (5.25 (±2.5) per minute) and seizures (n = 32) that appeared 7 (±0.8) days after SE. We found that CA3 was the seizure onset zone...Continue Reading

Citations

May 2, 2020·Epilepsy Currents·Atul Maheshwari
Sep 19, 2019·Epilepsy Currents·Shyam Kumar Sudhakar, Omar J Ahmed
Aug 28, 2020·Neuroinformatics·Gabriela J JurkiewiczJarosław Żygierewicz
Mar 5, 2021·Reviews in the Neurosciences·Maxime Lévesque, Massimo Avoli
Dec 29, 2020·International Journal of Neural Systems·Jianmin HaoDaqing Guo
Aug 3, 2021·Epilepsia·Laurent SheybaniSerge Vulliémoz

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