Phase-amplitude coupling between interictal high-frequency activity and slow waves in epilepsy surgery

Epilepsia
Hirotaka MotoiEishi Asano

Abstract

We hypothesized that the modulation index (MI), a summary measure of the strength of phase-amplitude coupling between high-frequency activity (>150 Hz) and the phase of slow waves (3-4 Hz), would serve as a useful interictal biomarker for epilepsy presurgical evaluation. We investigated 123 patients who underwent focal cortical resection following extraoperative electrocorticography recording and had at least 1 year of postoperative follow-up. We examined whether consideration of MI would improve the prediction of postoperative seizure outcome. MI was measured at each intracranial electrode site during interictal slow-wave sleep. We compared the accuracy of prediction of patients achieving International League Against Epilepsy class 1 outcome between the full multivariate logistic regression model incorporating MI in addition to conventional clinical, seizure onset zone (SOZ), and neuroimaging variables, and the reduced logistic regression model incorporating all variables other than MI. Ninety patients had class 1 outcome at the time of most recent follow-up (mean follow-up = 5.7 years). The full model had a noteworthy outcome predictive ability, as reflected by regression model fit R2 of 0.409 and area under the curve (AUC) o...Continue Reading

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Citations

Feb 13, 2020·Current Opinion in Neurology·Birgit Frauscher
Dec 10, 2019·Neurosurgery·Sarah E GoodaleDario J Englot
Apr 11, 2019·Journal of Neurophysiology·Daniel J MartireGeorge M Ibrahim
Sep 15, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Hiroki NariaiJoyce Y Wu
Mar 7, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Hiroharu SuzukiMahendranath Moharir
May 19, 2019·Seizure : the Journal of the British Epilepsy Association·Somin LeeShasha Wu

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