Phase angle is associated with advanced fibrosis in patients chronically infected with hepatitis C virus

Life Sciences
Mariana de Souza DornaGiovanni Faria Silva

Abstract

The objective of this study was to evaluate the association of phase angle (PhA) with advanced liver fibrosis in patients chronically infected with hepatitis C virus (HCV). One hundred sixty consecutive patients chronically infected with HCV were treated at the Hepatitis C outpatient care setting of our hospital from April 2010 to May 2011 and prospectively evaluated. Bioelectrical impedance analysis measurements were performed during the first hospital visit. Biochemical measurements and liver biopsy data were collected from the patients' medical records and included in the analysis only if they were performed within three months of the inclusion of the patient in the study. One hundred sixty consecutive patients were evaluated and 25 patients were excluded. A total of 135 patients with 49.8±11.4years old were studied. Among these patients, 60% were male and the PhA was 6.5±0.8°. Regarding the stage of fibrosis, patients with advanced fibrosis were older and had more insulin resistance and more inflammation compared with patients that had mild fibrosis. Logistic regression analysis revealed that PhA was a predictor of advanced fibrosis even when adjusted for gender, age, HOMA-IR, HDL-cholesterol and AST (OR: 0.227; CI 95%: 0.0...Continue Reading

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Citations

May 27, 2017·Current Opinion in Clinical Nutrition and Metabolic Care·Henry C LukaskiJens Kondrup
Jul 19, 2018·World Journal of Gastroenterology : WJG·Claudio Augusto MarroniAjacio Bandeira de Mello Brandão
Dec 18, 2020·Arquivos De Gastroenterologia·Kalinca S OliveiraGabriela P Coral

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