Phase behavior of stratum corneum lipid mixtures based on human ceramides: the role of natural and synthetic ceramide 1

The Journal of Investigative Dermatology
J A BouwstraMaja Ponec

Abstract

In a recent study the lipid phase behavior of mixtures of human ceramides, cholesterol, and free fatty acids has been examined. We observed in cholesterol: human ceramide mixtures a prominent formation of the 12.8 nm lamellar phase (referred to as the long periodicity phase). Addition of free fatty acids promoted the formation of a 5.6 nm lamellar phase (referred to as the short periodicity phase) and increased the subpopulation of lipids forming a fluid phase. In this study we focused on the role of human ceramide 1, as the presence of this ceramide appeared to be crucial for proper lipid phase behavior in mixtures prepared with ceramide isolated from pig stratum corneum. In order to do this, mixtures of cholesterol and free fatty acids were prepared with human ceramides, in which natural human ceramide 1 was replaced by either synthetic CER1-linoleate (CER1-lin), or CER1-oleate (CER1-ol), or CER1-stearate (CER1-ste). After substitution of natural human ceramide 1 by synthetic ceramide 1 the following observations were made. (i) In the presence of synthetic CER1-ste no long periodicity phase and no liquid phase could be detected. (ii) In the presence of HCER1-ol a liquid phase was more prominently formed than in the presence o...Continue Reading

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Citations

Jun 22, 2006·Contact Dermatitis·Cindy M De JonghSanja Kezic
Jan 1, 2011·Therapeutic Delivery·Kenneth B SloanScott C Wasdo
Apr 3, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sari PappinenArto Urtti
Jun 11, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Daniël GroenJoke A Bouwstra
Oct 16, 2004·The Journal of Investigative Dermatology·Miranda de JagerJoke Bouwstra
Mar 22, 2003·The Journal of Investigative Dermatology·Maria PonecPhil Wertz
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