Phase-change contrast agents for imaging and therapy.

Current Pharmaceutical Design
Paul S Sheeran, Paul A Dayton

Abstract

Phase-change contrast agents (PCCAs) for ultrasound-based applications have resulted in novel ways of approaching diagnostic and therapeutic techniques beyond what is possible with microbubble contrast agents and liquid emulsions. When subjected to sufficient pressures delivered by an ultrasound transducer, stabilized droplets undergo a phase-transition to the gaseous state and a volumetric expansion occurs. This phenomenon, termed acoustic droplet vaporization, has been proposed as a means to address a number of in vivo applications at the microscale and nanoscale. In this review, the history of PCCAs, physical mechanisms involved, and proposed applications are discussed with a summary of studies demonstrated in vivo. Factors that influence the design of PCCAs are discussed, as well as the need for future studies to characterize potential bioeffects for administration in humans and optimization of ultrasound parameters.

Citations

Apr 9, 2014·Applied Physics Letters·David S LiJoseph L Bull
Apr 9, 2014·Applied Physics Letters·David S LiJoseph L Bull
Jan 7, 2014·Advanced Drug Delivery Reviews·Shashank R Sirsi, Mark A Borden
Aug 10, 2013·The Journal of the Acoustical Society of America·Linsey C PhillipsPaul A Dayton
Aug 10, 2013·The Journal of the Acoustical Society of America·Oleksandr ShpakMichel Versluis
Dec 3, 2014·Colloids and Surfaces. B, Biointerfaces·Ghaleb A HusseiniAna M Martins
Feb 3, 2016·Ultrasound in Medicine & Biology·Andrew John HealeyJonny Østensen
Jan 16, 2016·Therapeutic Delivery·Roberta CavalliMonica Argenziano
Jul 16, 2013·Ultrasound in Medicine & Biology·Dhaval ThakkarNatalya Rapoport
Mar 19, 2013·Ultrasonics·Mallika Sridhar-KeralapuraMaryam Mobed-Miremadi
Mar 5, 2013·Ultrasound in Medicine & Biology·Paul S SheeranPaul A Dayton
Jan 3, 2016·The Journal of the Acoustical Society of America·Matthieu Guédra, François Coulouvrat
Mar 19, 2013·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·K Heath Martin, Paul A Dayton
Oct 8, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cherry C ChenElisa E Konofagou
Jan 23, 2014·Proceedings of the National Academy of Sciences of the United States of America·Oleksandr ShpakMichel Versluis
May 15, 2016·International Journal of Biological Macromolecules·Fatemeh BaghbaniSepideh Hamedi
Aug 31, 2016·Advances in Colloid and Interface Science·Paul A Mountford, Mark A Borden
Aug 27, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Donald A FernandesMichael C Kolios
Nov 5, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Joseph P MarshalekTerry O Matsunaga
Oct 12, 2016·Ultrasound in Medicine & Biology·Paul S SheeranPeter N Burns
Nov 12, 2015·Therapeutic Advances in Gastroenterology·Tatiana D KhokhlovaJoo Ha Hwang
Jun 27, 2014·Chemical Society Reviews·Liming Nie, Xiaoyuan Chen
Jan 24, 2014·Nature Materials·Chun Li
Jan 28, 2017·Journal of Therapeutic Ultrasound·Samantha M FixChristopher B Arena
Nov 5, 2014·Lab on a Chip·Paul RademeyerEleanor Stride
Nov 5, 2016·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Helen MulvanaEleanor Stride
Nov 18, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Carly PellowGang Zheng
Aug 5, 2017·Science·Raag Airan
Oct 16, 2016·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Juan D Rojas, Paul A Dayton
Sep 7, 2013·Journal of Biomechanical Engineering·Christopher B ArenaRafael V Davalos
Dec 20, 2013·Physics in Medicine and Biology·Paul S SheeranPaul A Dayton
Feb 1, 2018·Physics in Medicine and Biology·Shengtao LinMeng-Xing Tang

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