Phase-Contrast Hounsfield Units of Fixated and Non-Fixated Soft-Tissue Samples

PloS One
Marian WillnerJulia Herzen

Abstract

X-ray phase-contrast imaging is a novel technology that achieves high soft-tissue contrast. Although its clinical impact is still under investigation, the technique may potentially improve clinical diagnostics. In conventional attenuation-based X-ray computed tomography, radiological diagnostics are quantified by Hounsfield units. Corresponding Hounsfield units for phase-contrast imaging have been recently introduced, enabling a setup-independent comparison and standardized interpretation of imaging results. Thus far, the experimental values of few tissue types have been reported; these values have been determined from fixated tissue samples. This study presents phase-contrast Hounsfield units for various types of non-fixated human soft tissues. A large variety of tissue specimens ranging from adipose, muscle and connective tissues to liver, kidney and pancreas tissues were imaged by a grating interferometer with a rotating-anode X-ray tube and a photon-counting detector. Furthermore, we investigated the effects of formalin fixation on the quantitative phase-contrast imaging results.

References

Nov 1, 1991·Plastic and Reconstructive Surgery·F M GolombM J Levenstein
Dec 1, 1986·The British Journal of Radiology·H Q Woodard, D R White
Aug 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C H FoxP P Roller
Jun 1, 1995·Journal of the American Academy of Dermatology·M J Hudson-PeacockC M Lawrence
Apr 23, 2003·Archives of Dermatology·Neil GregoryViktor Goncharuk
Mar 16, 2007·Physical Review Letters·F PfeifferC David
Jul 8, 2008·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Shu-Ang Zhou, Anders Brahme
Nov 11, 2008·Annals of Diagnostic Pathology·René J Buesa
Feb 3, 2009·The British Journal of Dermatology·J N DauendorfferS Fraitag
Aug 8, 2005·Optics Express·Timm WeitkampEric Ziegler
Apr 20, 2010·Physics in Medicine and Biology·Zhihua QiGuang-Hong Chen
Jul 28, 2010·Journal of the Royal Society, Interface·Georg SchulzBert Müller
Apr 28, 2011·Medical Physics·Michael ChabiorFranz Pfeiffer
Dec 12, 2012·Physics in Medicine and Biology·Alberto BravinPekka Suortti
Apr 9, 2013·Skeletal Radiology·Thomas ThüringMarco Stampanoni
Mar 13, 2014·Physics in Medicine and Biology·M WillnerF Pfeiffer

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Citations

Dec 29, 2016·European Journal of Radiology·Vivien RichterAlexander A Fingerle
May 25, 2018·AJR. American Journal of Roentgenology·Seyedamir Tavakoli TabaPatrick C Brennan
Feb 1, 2017·Physics in Medicine and Biology·P BaranT E Gureyev
Aug 23, 2017·Surgical and Radiologic Anatomy : SRA·Anna SeidelRagai-Edward Matta
May 7, 2021·BioMed Research International·Ramin RanjbarzadehMersedeh Kooshki Forooshani
Apr 11, 2016·ACS Biomaterials Science & Engineering·Stacey M FortonErik M Shapiro

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Methods Mentioned

BETA
X-ray

Software Mentioned

OsiriX

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