Phase-contrast X-ray computed tomography for observing biological soft tissues

Nature Medicine
A MomoseK Hirano

Abstract

Biological soft tissues are almost transparent to hard X rays and therefore cannot be investigated without enhancement with a contrast medium, such as iodine. On the other hand, phase-contrast X-ray imaging is sensitive to light elements (1-8). This is because the X-ray phase shift cross section is almost thousand times larger than the X-ray absorption cross section for light elements such as hydrogen, carbon, nitrogen and oxygen (4,5). Hence, phase-contrast X-ray imaging is a promising technique for observing the structure inside biological soft tissues without the need for staining and without serious radiation exposure. We have devised a means of observing biological tissues in three dimensions using a novel X-ray computed tomography (CT) by modifying the phase-contrast technique. To generate appropriate CT input data, we used phase-mapping images obtained using an X-ray interferometer (6) and computer analysis of interference patterns (9). Now, we present a three-dimensional observation result of a nonstained sample of a cancerous rabbit liver, using a synchrotron X-ray source. Phase-contrast X-ray CT was able to clearly differentiate the cancer lesion from the normal tissue. Moreover, fine structures corresponding to cance...Continue Reading

References

Apr 1, 1995·Medical Physics·A Momose, J Fukuda
Oct 1, 1995·Academic Radiology·A MomoseY Itai

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Citations

Mar 23, 2010·Analytical and Bioanalytical Chemistry·Zhili WangZiyu Wu
Apr 2, 2010·Analytical and Bioanalytical Chemistry·Zhili WangZiyu Wu
Apr 16, 2010·Analytical and Bioanalytical Chemistry·Kai ZhangZiyu Wu
Jun 1, 2011·Analytical and Bioanalytical Chemistry·Kai ZhangZiyu Wu
Jan 1, 2009·Radiological Physics and Technology·Akihiro OsawaJun Onagawa
Feb 5, 2013·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·F ScattarellaR Bellotti
Jan 1, 1996·Progress in Biophysics and Molecular Biology·U Bonse, F Busch
Aug 1, 1996·Nature Medicine·A Momose, T Takeda
Jul 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Peiping ZhuMarco Stampanoni
Oct 24, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yunzhe ZhaoAlberto Bravin
Feb 12, 2008·Physics in Medicine and Biology·Guang-Hong Chen, Zhihua Qi
Apr 20, 2010·Physics in Medicine and Biology·Zhihua QiGuang-Hong Chen
Apr 12, 2012·Physics in Medicine and Biology·Pascal Thériault LauzierGuang-Hong Chen
Nov 17, 2009·Cerebral Cortex·Ryuta MizutaniYoshio Suzuki
Dec 20, 2008·Journal of Synchrotron Radiation·Martin BechFranz Pfeiffer
Dec 6, 2012·Biology Open·Masato HoshinoNaoto Yagi
Aug 24, 2010·AJR. American Journal of Roentgenology·Xi ZhangShao-Liang Chen
Jan 5, 2011·The Review of Scientific Instruments·Takashi KimuraKazuto Yamauchi
Aug 3, 2011·The Review of Scientific Instruments·K IgnatyevA Olivo
Aug 7, 2010·The Review of Scientific Instruments·Vincent RevolClaus Urban
Nov 26, 2010·Medical Physics·Wenxiang Cong, Ge Wang
Jan 29, 2014·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Alessandro Olivo, Ian Robinson
Dec 8, 2010·The Review of Scientific Instruments·Frantisek KrejciMartin Kroupa
Jun 2, 2014·The Review of Scientific Instruments·T P MillardA Olivo
Jul 12, 2014·Annual Review of Biomedical Engineering·Daniel Thomas Ginat, Rajiv Gupta
Jul 6, 2014·Medical Physics·C K HagenA Olivo
May 29, 2014·Pharmaceutical Research·Jennifer WongHak-Kim Chan
May 24, 2003·The British Journal of Radiology·R A LewisK D Rogers
Jun 21, 2011·The International Journal of Cardiovascular Imaging·Masafumi TakedaKen-Ichi Hirata

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