Phase contrast x-ray velocimetry of small animal lungs: optimising imaging rates

Biomedical Optics Express
Rhiannon P MurrieKaye S Morgan

Abstract

Chronic lung diseases affect a vast portion of the world's population. One of the key difficulties in accurately diagnosing and treating chronic lung disease is our inability to measure dynamic motion of the lungs in vivo. Phase contrast x-ray imaging (PCXI) allows us to image the lungs in high resolution by exploiting the difference in refractive indices between tissue and air. Combining PCXI with x-ray velocimetry (XV) allows us to track the local motion of the lungs, improving our ability to locate small regions of disease under natural ventilation conditions. Via simulation, we investigate the optimal imaging speed and sequence to capture lung motion in vivo in small animals using XV on both synchrotron and laboratory x-ray sources, balancing the noise inherent in a short exposure with motion blur that results from a long exposure.

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Citations

Aug 30, 2016·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Goran LovricMarco Stampanoni
Feb 7, 2018·Optics Express·G W GoonanS Dubsky
Jun 17, 2020·Scientific Reports·Stephanie KulpeDaniela Pfeiffer
May 3, 2018·Scientific Reports·Regine GradlKaye Susannah Morgan

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