Phase-dependent modulation as a novel approach for therapeutic brain stimulation

Frontiers in Computational Neuroscience
Ramin Azodi-Avval, Alireza Gharabaghi

Abstract

Closed-loop paradigms provide us with the opportunity to optimize stimulation protocols for perturbation of pathological oscillatory activity in brain-related disorders. In this vein, spiking activity of motor cortex neurons and beta activity of local field potentials in the subthalamic nucleus have both been used independently of each other as neuronal signals to trigger deep brain stimulation for alleviating Parkinsonism. These approaches were superior to the standard continuous high-frequency stimulation protocols used in daily practice. However, they achieved their effects by bursts of stimulation that were applied at high-frequency as well, i.e., independent of the phase information in the stimulated region. In this context, we propose that, by timing stimulation pulses relative to the ongoing oscillation, an alternative approach, namely the targeted perturbation of pathological rhythms, could be obtained. In this modeling study, we first captured the underlying dynamics of neuronal oscillations in the human subthalamic nucleus by phased coupled neuronal oscillators. We then quantified the nature of the interaction between these coupled oscillators by obtaining a physiologically informed phase response curve from local fie...Continue Reading

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Citations

Sep 29, 2015·Parkinsonism & Related Disorders·M Beudel, P Brown
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Nov 3, 2020·Frontiers in Neuroscience·Brian Y HwangKelly A Mills

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Methods Mentioned

BETA
PCRs

Software Mentioned

MATLAB
DAMOCO
Fieldtrip
WPLI

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