Phase I dose escalation study of carboplatin to a fixed dose of irinotecan as first-line treatment of small cell lung cancer

Onkologie
A SchmittelU Keilholz

Abstract

Superiority of irinotecan (CPT-11) plus cisplatin over etoposide plus cisplatin in small cell lung cancer (SCLC) has recently been demonstrated. This study determines dose-limiting toxicity (DLT) and maximum tolerated dose (MTD) of escalating doses of carboplatin to a fixed dose of irinotecan in Caucasians with small cell lung cancer. Patients with extensive small cell lung cancer received 50 mg/m(2) irinotecan on day 1, 8, and 15. Dose escalation of carboplatin on day 1 started in dose level 1 at an AUC of 5 mg x min/ml and was escalated to AUC 6 in level 2. Cycles were repeated on day 29. Dose escalation was evaluated after 3 consecutive patients. If no grade IV neutropenia lasting for > or =7 days or thrombopenia or non-hematologic toxicity > or = grade III occurred, treatment was continued in the next dose level. 16 patients were treated. DLT was reached in dose level 2 with 2 grade IV neutropenias and 1 grade IV thrombopenia and diarrhea. Toxicity was further investigated at dose level 1 in a total of 10 patients, which revealed 2 grade III neutropenias and 1 grade III diarrhea. Of 15 evaluable patients, 10 had a partial response, 3 had disease stabilization and 2 progressed. Dose level 1 was found to be MTD, this dose is ...Continue Reading

Citations

Apr 20, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Eckart LaackCarsten Bokemeyer
Jan 27, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A SchmittelUNKNOWN Arbeitsgemeinschaft Internistische Onkologie Thoracic Oncology Study Group
May 29, 2012·Current Problems in Cancer·Ariel Lopez-Chavez, Alan Sandler
Oct 3, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Joo Hyuk SohnJoo-Hang Kim
Jun 20, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hiroaki OkamotoKoshiro Watanabe

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