PMID: 1203838Jul 1, 1975Paper

Phase I study of ftorafur, an analog of 5-fluorouracil

Cancer
C R SmartS J Manning

Abstract

Ftorafur, a furanyl analog of 5-fluorouracil (5-FU), is reported to be five to six times less toxic and possibly more effective in cancer of the breast and colon than 5-FU. The drug was synthesized, formulated, and utilized in toxicologic studies, and then in 24 patients with advanced incurable malignancies. When Ftorafur is given by intravenous push, it results in immediate flushing, dizziness, nausea, retching, and in some cases transient hypotension. These immediate side effects are largely eliminated by administering the drug slowly by infusion. In patients, 60 mg/kg of Ftorafur given i.v. daily for up to 10 days resulted in mild toxicity. However, 80 mg/kg given i.v. daily for 7 days resulted in severe toxicity, with nausea, vomiting, stomatitis, leukopenia, and thrombocytopenia. These studies confirm those of the Russian investigators as to toxicity and dosage, even with a different method of administration more convenient for therapy. Phase II studies are presently being carried out to compare the effectiveness of Ftorafur and 5-FU.

References

Aug 1, 1972·Cancer·N G BlokhinaA M Garin
Jan 1, 1965·The American Journal of the Medical Sciences·N L CRESSY, H W SCHELL

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Citations

Sep 27, 2000·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M FeinM Weig
Jan 1, 1990·Acta Oncologica·N Keldsen, M Dalmark
Nov 1, 1982·International Journal of Radiation Oncology, Biology, Physics·J E ByfieldF Kulhanian
Mar 1, 1985·International Journal of Radiation Oncology, Biology, Physics·J E ByfieldJ C Griffiths
Dec 1, 1980·Cancer Treatment Reviews·M A Friedman, R J Ignoffo
Oct 1, 1987·British Journal of Obstetrics and Gynaecology·M UekiT Maeda
Oct 1, 1987·Medicinal Research Reviews·K T Douglas
Nov 30, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L CireraM Boleda

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