Phase I study of intravenous vascular endothelial growth factor trap, aflibercept, in patients with advanced solid tumors.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
A Craig LockhartWilliam P Tew

Abstract

Vascular endothelial growth factor (VEGF) Trap (aflibercept) is an angiogenesis inhibitor comprising portions of the extracellular domains of human VEGF receptors 1 and 2 fused to the Fc portion of human immunoglobulin G. This phase I study was designed to evaluate the safety, pharmacokinetics, and pharmacodynamics of VEGF Trap administered intravenously (IV) every 2 weeks. Patients with refractory solid tumors or non-Hodgkin's lymphoma with adequate organ function were eligible. Pharmacokinetic/pharmacodynamic markers included measurement of plasma VEGF bound to VEGF Trap and free VEGF Trap. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) was incorporated to measure the biologic effects of the drug on tumor vascularity and permeability. The study enrolled 47 patients at doses ranging from 0.3 to 7.0 mg/kg IV every 2 weeks. Dose-limiting toxicities were rectal ulceration and proteinuria at the 7.0 mg/kg dose. Other mechanism-specific toxicities included hypertension. On the basis of these observations and on pharmacokinetics, the recommended phase II dose of VEGF Trap as a single agent is 4 mg/kg every 2 weeks. Three RECIST (Response Evaluation Criteria in Solid Tumors) -defined partial responses were observed, o...Continue Reading

References

Feb 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P S Tofts, A G Kermode
Nov 1, 1989·The Journal of Clinical Investigation·D T ConnollyJ Feder
Feb 1, 1997·Endocrine Reviews·N Ferrara, T Davis-Smyth
Dec 5, 2000·Current Opinion in Biotechnology·N Ferrara
Nov 1, 2001·Topics in Magnetic Resonance Imaging : TMRI·M V KnoppP Choyke
Aug 15, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jocelyn HolashJohn S Rudge
Jun 4, 2004·The New England Journal of Medicine·Herbert HurwitzFairooz Kabbinavar
Dec 16, 2005·Nature·Leigh CoultasJanet Rossant
Dec 15, 2006·The New England Journal of Medicine·Alan SandlerDavid H Johnson
Nov 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·John S RudgeGeorge D Yancopoulos
Dec 28, 2007·The New England Journal of Medicine·Kathy MillerNancy E Davidson
May 9, 2008·The New England Journal of Medicine·Robert S Kerbel

❮ Previous
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Citations

May 16, 2013·Cancer Chemotherapy and Pharmacology·Hoai-Thu ThaiEmmanuelle Comets
Jun 14, 2006·Cancer Metastasis Reviews·Harold J WaneboHope Rugo
Aug 17, 2010·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Ketao JinLisong Teng
Jun 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jenny YaoCarlos Bais
Jul 21, 2011·Physics in Medicine and Biology·David S SmithThomas E Yankeelov
Jan 22, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C NabhanW M Stadler
Apr 1, 1966·The Journal of Small Animal Practice·J Hasholt
Sep 10, 2011·Journal of Oncology·Angelica TrujilloChristopher R Cogle
Sep 2, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ahmad A TarhiniJohn M Kirkwood
Jul 14, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Julia Glade BenderJulie R Park
Aug 8, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Cindy H Chau, William D Figg
Feb 28, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kristen K CiomborEmily Chan
Jun 24, 2010·Molecular Cancer Therapeutics·Sumanta Kumar PalKaren Reckamp
Nov 3, 2012·Therapeutic Advances in Medical Oncology·Axel Grothey, Carmen Allegra
Aug 12, 2010·Journal of Angiogenesis Research·Steven P WilliamsSteven A Stacker
May 25, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John F de GrootPatrick Y Wen
Jun 12, 2010·Journal of the American Society of Nephrology : JASN·Shenhong WuXiaolei Zhu
Aug 29, 2012·International Journal of Women's Health·Ramez N Eskander, Krishnansu S Tewari
Jun 22, 2011·OncoTargets and Therapy·Marc S Ballas, Abraham Chachoua
Jan 5, 2011·Frontiers in Bioscience (Landmark Edition)·Jun CaiMichael E Boulton
Jul 16, 2014·Immunology and Allergy Clinics of North America·Brian A Baldo, Mauro Pagani
Nov 5, 2014·Cancer Metastasis Reviews·J Michael RandallRazelle Kurzrock
Oct 12, 2011·Investigational New Drugs·George R Blumenschein
Jun 5, 2012·Investigational New Drugs·Shannon N WestinRobert L Coleman
Aug 28, 2013·European Radiology·M J GollubP B Paty
Mar 15, 2012·Langenbeck's Archives of Surgery·L V KlotzChristiane J Bruns
Jan 21, 2015·Seminars in Cancer Biology·Zongwei WangLasse D Jensen
May 17, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sadhna AggarwalSatya N Das
Mar 5, 2014·Expert Opinion on Drug Safety·Shuang ZhangYuquan Wei
May 23, 2012·Expert Opinion on Investigational Drugs·Teresa TroianiFloriana Morgillo
May 20, 2015·Expert Opinion on Drug Metabolism & Toxicology·Enrique Sanz-GarciaTeresa Macarulla
Jul 28, 2015·Expert Opinion on Investigational Drugs·Yeh Chen LeeJohn R Zalcberg
Dec 19, 2014·Expert Opinion on Investigational Drugs·Manik Amin, Albert Craig Lockhart
Mar 12, 2011·Expert Opinion on Investigational Drugs·Ivan Diaz-Padilla, Lillian L Siu
Feb 13, 2015·Expert Opinion on Biological Therapy·Hironori Nakagami, Ryuichi Morishita
Aug 26, 2014·Expert Opinion on Biological Therapy·Teresa MacarullaJosep Tabernero
Dec 4, 2012·Expert Opinion on Biological Therapy·Joel W Neal, Heather A Wakelee

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