Phase I trial and pharmacokinetic analysis of ifosfamide in cats with sarcomas

American Journal of Veterinary Research
Kenneth M RassnickRodney L Page

Abstract

To determine the maximally tolerated dose (MTD) and dose-limiting toxicosis (DLT) of ifosfamide in tumor-bearing cats. 38 cats with resected, recurrent, or metastatic sarcomas. The starting dosage of ifosfamide was 400 mg/m(2) of body surface area, IV, and dosages were increased by 50 to 100 mg/m(2) in cohorts of 3 cats. To protect against urotoxicosis, mesna was administered at a dosage equal to 20% of the calculated ifosfamide dosage. Diuresis with saline (0.9% NaCl) solution before and after administration of ifosfamide was used to minimize nephrotoxicosis. Samples for pharmacokinetic analysis were obtained after the MTD was reached. 38 cats were entered into this phase I study and were administered a single dose of ifosfamide at various dosages. The MTD was 1,000 mg/m(2), and neutropenia was the DLT. Seven of 8 episodes of neutropenia were on day 7 after treatment, and 1 cat developed severe neutropenia on day 5. Adverse effects on the gastrointestinal tract were generally mild and self-limiting, the most common of which was nausea during ifosfamide infusion. One cat had signs consistent with a drug-induced hypersensitivity reaction. There were no episodes of hemorrhagic cystitis or nephrotoxicosis. Correlations between pha...Continue Reading

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Mar 2, 2006·American Journal of Veterinary Research·Kenneth M RassnickRodney L Page

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Citations

Nov 13, 2008·Journal of Veterinary Internal Medicine·D B BaileyC E Balkman
Mar 2, 2006·American Journal of Veterinary Research·Kenneth M RassnickRodney L Page
Feb 14, 2013·Journal of Feline Medicine and Surgery·Daniel J BatchelorAlexander J German
Apr 23, 2013·Journal of Feline Medicine and Surgery·Michael Sean Kent

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