PMID: 9439648Jan 24, 1998Paper

Phase I trial of adoptive immunotherapy of cancer patients using monocyte-derived macrophages activated with interferon gamma and lipopolysaccharide

Cancer Immunology, Immunotherapy : CII
B HennemannR Andreesen

Abstract

Cells of the monocyte/macrophage lineage have shown antitumor activity in vitro and in murine models after activation with interferon (IFN) gamma. In vitro data suggest an additional effect on macrophage antitumor activity when IFN gamma is combined with endotoxin (lipopolysaccharides; LPS). In this study we treated nine cancer patients with a total of 62 MAK infusion cycles with autologous macrophages given intravenously (i.v.) after in vitro activation with IFN gamma and LPS. Low-grade fever (WHO I/II) was the commonest side-effect. Chills, nausea, and headache were noted when the number of transfused macrophages exceeded 2 x 10(8). One WHO IV toxicity occurred, consisting of hypotension after transfer of 3 x 10(8) cells, defining this dose as the maximum cell number tolerated. After pretreatment with ibuprofen, however, the maximum cell number could be increased without reaching dose-limiting toxicity. The highest number of cells reinfused was 15 x 10(8). Circulating interleukin(IL)-6 increased in a dose-dependent manner as did IL-1 receptor antagonist (IL-1RA) and IL-8. Tumor response consisted of one case of stable disease (12 weeks) in a patient with formerly progressing colorectal cancer and progressive diseases in eight...Continue Reading

Citations

Mar 13, 2003·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Stephen J WagnerAlfred J Katz
Feb 6, 2010·Expert Opinion on Biological Therapy·Jennifer A WestwoodMichael H Kershaw
Mar 4, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexander BagaevRavshan I Ataullakhanov
May 2, 2009·Journal of Leukocyte Biology·Andrew J FleetwoodJohn A Hamilton
Jul 28, 2019·Cancer Research·Dominique C Hinshaw, Lalita A Shevde
Jan 31, 2021·Vaccines·Joel MintzHimanshu Arora
Nov 5, 2002·Critical Reviews in Oncology/hematology·A H KlimpT Daemen
Sep 19, 2018·Molecular Pharmaceutics·Maryam A Shetab Boushehri, Alf Lamprecht

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.