Phase I Trial of DNX-2401 for Diffuse Intrinsic Pontine Glioma Newly Diagnosed in Pediatric Patients

Neurosurgery
Sonia TejadaRicardo Diez-Valle

Abstract

There are no effective treatments for diffuse intrinsic pontine gliomas (DIPGs); these tumors cannot be surgical resected, and diagnosis is based on magnetic resonance imaging. As a result, tumor tissues for molecular studies and pathologic diagnosis are infrequent. New clinical trials are investigating novel medications and therapeutic techniques in an effort to improve treatment of patients with DIPGs. To determine the safety, tolerability, and toxicity of an oncolytic adenovirus, DNX-2401, injected into the cerebellar peduncle in pediatric subjects with DIPG and to collect tumor samples of this type of tumor. Phase I, single-center, uncontrolled trial. A tumor biopsy will be performed through the cerebellar peduncle, and DNX-2401 will be injected immediately after the biopsy. Standard therapy consisting of radiotherapy and chemotherapy will follow in 2 to 6 wk. Improvement of overall survival and quality of life in patients with DIPG and collection of tumor specimens to study the molecular profiling of these tumors. The aims of this trial are to contribute to the sample collection of DIPG and to offer treatment during the tumor tissue biopsy using the virus. If this virus works as expected, it could kill the tumor cells with...Continue Reading

Citations

Jan 18, 2018·Brain Sciences·Mayra PaolilloSergio Schinelli
May 30, 2019·Nature Communications·Naiara Martínez-VélezMarta M Alonso
May 28, 2020·Neuro-oncology·Phonphimon WongthidaRichard G Vile
Feb 6, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Sonia TejadaUlrich-W Thomale
Jun 22, 2020·Current Neurology and Neuroscience Reports·Elizabeth S Duke, Roger J Packer
Dec 14, 2018·Oncoimmunology·Jonathan G PolLorenzo Galluzzi
Jul 11, 2018·Cancers·Maider Varela-GuruceagaMarta M Alonso
Dec 11, 2020·Brain : a Journal of Neurology·James L RossDolores Hambardzumyan
Dec 31, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marc Garcia-MoureMarta M Alonso
Mar 20, 2021·Journal of Medical Virology·Weijian LinLiping Zhong
Feb 3, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Martí Farrera-SalRamon Alemany
Jun 25, 2021·Frontiers in Immunology·Concetta QuintarelliBiagio De Angelis
Apr 16, 2021·Brain : a Journal of Neurology·James L RossDolores Hambardzumyan

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