Abstract
Eribulin mesylate, an halichondrin B analog, binds to tubulin and microtubules and possesses broad anti-cancer activity. We conducted a multi-institutional Phase II trial to evaluate the response rate of eribulin mesylate in patients with metastatic or recurrent squamous cell carcinoma of the head and neck (SCCHN). Forty eligible patients who had not received prior chemotherapy for metastatic or recurrent SCCHN were enrolled with the following characteristics: 29 male, 11 female; median age 61.2 years; Zubrod Performance Status of 0 (48%) and 1 (53%). Thirty-three patients (83%) had metastatic disease. Primary tumor sites included: 38% oropharynx, 30% lip/oral cavity, 15% larynx, 10% hypopharynx, 5% other/unknown and 3% nasopharynx. Patients received eribulin mesylate at 1.4 mg/m² on Days 1 and 8 of an every 21-day cycle. Common Grade 3 and 4 toxicities included: lymphopenia (15%), leukocytopenia (13%), neutropenia (10%), hyponatremia (5%), fatigue (5%), diarrhea (5%) and dyspnea (5%), with one treatment-related death due to pulmonary hemorrhage. Among 40 assessable patients, two confirmed partial responses were observed, for an estimated confirmed response rate of 5% (95% confidence interval: 1-17%). The estimated median progr...Continue Reading
References
Aug 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A A ForastiereS K Williamson
Feb 3, 2000·Journal of the National Cancer Institute·P TherasseS G Gwyther
Mar 12, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G Numico, M Merlano
Mar 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bonnie S GlissonArlene A Forastiere
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Atsushi OhtsuUNKNOWN Japan Clinical Oncology Group Study (JCOG9205)
May 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael K GibsonUNKNOWN Eastern Cooperative Oncology Group
Jul 13, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roy S HerbstMerrill S Kies
Jul 16, 2005·Molecular Cancer Therapeutics·Mary Ann JordanLeslie Wilson
Sep 10, 2005·Clinical Oncology : a Journal of the Royal College of Radiologists·X LeónJ Bourhis
Nov 23, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric H RubinAmit M Oza
Nov 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Barbara BurtnessUNKNOWN Eastern Cooperative Oncology Group
Jun 17, 2006·Cancer·Francis P WordenUNKNOWN Southwest Oncology Group, Head and Neck Working Group
Aug 31, 2006·Molecular Pharmacology·Donnette A DabydeenErnest Hamel
May 29, 2007·Cancer Investigation·Wolfram E SamlowskiJohn F Ensley
Jun 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jan B VermorkenJosé Baselga
Jun 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lillian L SiuUNKNOWN National Cancer Institute of Canada Clinical Trials Group Study
May 17, 2008·Cancer·Jan B VermorkenJose Baselga
Jul 23, 2008·Molecular Cancer Therapeutics·Tatiana OkounevaMary Ann Jordan
Aug 22, 2008·Oral Oncology·Pol M Specenier, Jan B Vermorken
Sep 12, 2008·The New England Journal of Medicine·Jan B VermorkenRicardo Hitt
Sep 12, 2008·The New England Journal of Medicine·Robert I Haddad, Dong M Shin
Feb 10, 2009·The Lancet Oncology·Ezra E W CohenEverett E Vokes
Apr 8, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Linda T VahdatJoanne L Blum
Sep 10, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J S de BonoD P Petrylak
Citations
Apr 29, 2011·Investigational New Drugs·Daniel J RenoufMalcolm J Moore
May 5, 2011·Journal of Chemical Information and Modeling·Ruoli BaiErnest Hamel
Apr 28, 2010·Natural Product Reports·James J La Clair
May 26, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephen K WilliamsonSusan G Urba
Mar 12, 2008·World Journal of Gastroenterology : WJG·Soonmo Peter KangJill Lacy
Apr 9, 2013·Oncology Reports·Smita MehtaStephen Williamson
Jan 27, 2016·Expert Opinion on Pharmacotherapy·Olexiy AseyevF Cardoso
Aug 12, 2015·Marine Drugs·Umang SwamiSanjay Goel
May 24, 2014·Expert Review of Anticancer Therapy·Laura PolastroAhmad Awada
Jun 29, 2012·Clinical Therapeutics·Sarah L Scarpace
Mar 5, 2016·European Journal of Pharmacology·George LiamisMoses S Elisaf
Apr 18, 2013·Journal of breast cancer·Alaaeldin Shablak
May 24, 2012·The Annals of Pharmacotherapy·Jessica N Preston, Meghana V Trivedi
Jul 13, 2018·Expert Review of Anticancer Therapy·Pol Specenier, Jan B Vermorken
Jun 13, 2019·Oncology Letters·Yutaka KobayashiShuichi Kawashiri
Jun 9, 2020·Frontiers in Oncology·Ignazio VerziccoAderville Cabassi
Apr 13, 2012·Current Opinion in Oncology