Phase II investigation of docetaxel in pediatric patients with recurrent solid tumors: a report from the Children's Oncology Group

Cancer
Ted ZwerdlingChildren's Oncology Group

Abstract

Docetaxel, which is an antitubulin agent, has demonstrable activity against murine and human tumors. The current study was designed to determine response rates to docetaxel in various strata of recurrent solid tumors of childhood and to assess toxicity in a group of patients who were assigned to receive it. Docetaxel was given at a dose of 125 mg/m2 once every 21 days as a 1-hour intravenous infusion for a maximum of 12 courses. From January 1997 to November 2001, 109 male patients and 68 female patients (total, 177 patients) were enrolled, and 173 patients were eligible. The median patient age at entry was 13 years (range, 1-27 yrs). One hundred sixty patients were evaluable for response. There were no deaths attributable to study drug. Hematologic toxicity was common during therapy. Dermatologic, neurologic, pulmonary, and infectious side effects as well as edema were significant. One patient each had acute myeloid leukemia, acute lymphoid leukemia, and high-grade glioma reported as secondary malignancies. One patient with osteosarcoma and 1 patient with rhabdomyosarcoma achieved a complete response. Partial responses were observed in patients with Ewing sarcoma (3 patients), osteosarcoma (1 patient), squamous cell carcinoma ...Continue Reading

References

Feb 20, 1991·Journal of the National Cancer Institute·I Ringel, S B Horwitz
Jun 25, 1988·British Medical Journal·L G Cohen, J P Rovers
Dec 1, 1982·American Journal of Clinical Oncology·M M OkenP P Carbone
Jul 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E TomiakV Auzannet
Jun 18, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Martee L HensleyDavid R Spriggs
Mar 6, 2003·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Maurie Markman
Apr 19, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P L R MitchellM Green
May 29, 2003·Current Medicinal Chemistry. Anti-cancer Agents·Valérie Ganansia-LeymarieVincent Holl
Sep 17, 2003·Apoptosis : an International Journal on Programmed Cell Death·F Mollinedo, C Gajate
Oct 28, 2003·Investigational New Drugs·Lisa Ann KrausMarie Christine Bissery
Apr 3, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Aurora BrønstadRolf K Reed
May 25, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Frederike K Engels, Jaap Verweij

❮ Previous
Next ❯

Citations

Jun 24, 2009·Current Treatment Options in Oncology·Wesley HsuJean-Paul Wolinsky
Sep 4, 2009·Journal of Pediatric Hematology/oncology·Jaume MoraCarmen de Torres
Apr 4, 2012·Journal of Pediatric Hematology/oncology·Sally L GeorgePenelope Brock
Sep 26, 2012·Journal of Pediatric Hematology/oncology·Pooja HingoraniMasayo Watanabe
Jan 14, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shana JacobsBrigitte C Widemann
Mar 1, 2008·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Eui Bae KimSeok Jin Kim
Jun 5, 2014·Current Oncology Reports·Aaron WeissDamon Reed
Jul 8, 2015·Pediatric Blood & Cancer·Sarah WinterDaniel Orbach
Oct 8, 2013·Hematology/oncology Clinics of North America·Jolieke G van OosterwijkJudith V M G Bovée
Jul 30, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Gisela G SlaatsRachel H Giles
Apr 9, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jeong-A ParkThad T Ghim
Aug 3, 2007·Pediatric Blood & Cancer·Janet L FranklinUNKNOWN Children's Oncology Group
Jun 1, 2012·Pediatric Blood & Cancer·Angela D Trobaugh-Lotrario, James H Feusner
Feb 4, 2012·Pediatric Blood & Cancer·Louis RapkinHoward M Katzenstein
Jan 7, 2014·Cancer Treatment Reviews·N U GerberS Rutkowski
May 29, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Véronique Minard-ColinOdile Oberlin
Aug 21, 2014·Neuro-oncology·Emily GirardJames Olson
Jun 17, 2016·Expert Review of Neurotherapeutics·Antonin DréanAhmed Idbaih
Sep 25, 2016·Cancer Treatment Reviews·Tejaswi KandulaMichelle A Farrar
Jul 13, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joanne P LagmayKatherine A Janeway
Aug 26, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael S IsakoffRichard Gorlick
Oct 10, 2006·Future Oncology·Abha A Gupta, Alberto S Pappo
Jul 6, 2019·Frontiers in Oncology·Dana L CaseyNai-Kong V Cheung
Feb 6, 2019·Oncotarget·Kenta WatanabeTomoatsu Kimura
Nov 9, 2018·Oncology Letters·Ya ZhangZuozhang Yang
Sep 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Vaani GargE Anders Kolb
May 1, 2021·Cancers·Ioanna GazouliAmanda Psyrri

❮ Previous
Next ❯

Related Concepts

Related Feeds

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
E LaackD K Hossfeld
Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Aruna KommareddyRamaswamy Govindan
© 2021 Meta ULC. All rights reserved