PMID: 2507125Nov 1, 1989Paper

Phase II randomized clinical trial of LC9018 concurrently used with radiation in the treatment of carcinoma of the uterine cervix. Its effect on tumor reduction and histology

Cancer
T OkawaS Hashimoto

Abstract

The clinical efficacy of LC9018, a biological response modifier prepared from heat-killed Lactobacillus casei YTT9018, used in combination with radiation was studied in a randomized controlled trial on 61 patients with carcinoma of the uterine cervix of Stage IIB or III. The combination therapy with LC9018 demonstrated a significant effect on tumor reduction, compared with radiation therapy alone, at the cumulative doses of 15-Gy and 30-Gy external irradiation (P less than 0.05). Histologic study confirmed that LC9018 also enhanced the therapeutic effect of the irradiation. Moreover, LC9018 seemed to be useful in protecting the patients from leukopenia during radiotherapy. This study suggests that LC9018, when used in combination with radiotherapy, will be an effective adjuvant immunotherapeutic agent. More studies in a large series of patients will, however, be needed to establish its long-term efficacy, safety, and effects on both prognosis and enhancing radiotherapy.

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Citations

Oct 15, 1990·Cancer Genetics and Cytogenetics·D PeruccaP Gaudray
Jul 1, 1991·Cancer Genetics and Cytogenetics·D P HuangJ C Lee
Jun 1, 1992·Cancer Genetics and Cytogenetics·N C Popescu, J A DiPaolo
Nov 1, 1993·Cancer Genetics and Cytogenetics·E F Allen, J H Lunde
Jan 1, 1995·Cancer Genetics and Cytogenetics·S Y ParkJ H Lee
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May 1, 1997·Cancer Genetics and Cytogenetics·N B Atkin
Jan 1, 2012·Microbial Ecology in Health and Disease·Sampo J Lahtinen
Nov 17, 2015·Expert Review of Anticancer Therapy·Gulden MenderesAlessandro D Santin
Nov 15, 1993·International Journal of Radiation Oncology, Biology, Physics·T AraiK Oka
Mar 6, 2008·The Journal of Medical Investigation : JMI·Yoshihiro TakegawaMasafumi Harada
Dec 20, 2014·Future Oncology·Andre M AgassiSteven E Finkelstein
Sep 1, 2018·The Cochrane Database of Systematic Reviews·Dang WeiRob Jpm Scholten
Aug 24, 2006·Japanese Journal of Clinical Oncology·Kiichiro NodaKeiichi Fujiwara

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