PMID: 11333130May 3, 2001Paper

Phase II randomized study of dacarbazine, carmustine, cisplatin and tamoxifen versus dacarbazine alone in advanced melanoma patients

Melanoma Research
V Chiarion SileniS Monfardini

Abstract

This randomized phase II trial was performed to define the activity and toxicity of the combination of dacarbazine (DTIC), carmustine (BCNU), cisplatin (DDP) and tamoxifen (DBDT regimen) versus DTIC alone in patients with metastatic melanoma. Sixty patients with metastatic melanoma were randomly assigned to receive BCNU 150 mg/m2 intravenously (i.v.) on day 1, cisplatin 25 mg/m2 i.v. daily on days 1 to 3, DTIC 220 mg/m2 i.v. daily on days 1 to 3 and tamoxifen 160 mg orally daily for 7 days prior to chemotherapy (DBDT arm; arm A). Treatment cycles were repeated every 28 days, while BCNU was given every two cycles. The DTIC arm (arm B) patients received DTIC alone 1200 mg/m2 i.v. on day 1, repeated every 21 days. Patients were evaluated every two cycles; responding patients continued the treatment for a maximum of 12 cycles. The overall response rate was 26% in the DBDT arm and 5% in the DTIC arm. Complete responses were 2.5% for DBDT and 0% for DTIC. The median progression-free survival and the median survival were 4 and 9 months, respectively for DBDT, and 2 and 7 months for DTIC. DBDT was associated with significant haematological toxicity: 33% of the patients experienced a grade III or IV neutropenia and 28% a grade III or IV...Continue Reading

References

Aug 20, 1992·The New England Journal of Medicine·G CocconiP Costa
Mar 1, 1984·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S D LuikartJ M Kirkwood
Feb 20, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K A MargolinV K Sondak
Mar 21, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·O EtonR S Benjamin
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E T CreaganJ C Michalak
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P B ChapmanJ M Kirkwood
Jan 7, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M R MiddletonN Thatcher

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Citations

Oct 31, 2002·Seminars in Oncology·Yan Li, Edward F McClay
Apr 25, 2006·Annals of Surgery·Charles R ScogginsUNKNOWN Sunbelt Melanoma Trial
Jul 5, 2006·Cancer Research·Takuji MoriDave S B Hoon
Oct 10, 2012·BMC Medical Research Methodology·Jeroen P Jansen, Shannon Cope
Sep 18, 2012·Chinese Journal of Cancer·Xing LuYan-Qun Xiang
May 11, 2011·Expert Review of Anticancer Therapy·Glen M Boyle
May 19, 2009·Expert Review of Anticancer Therapy·Ryan J Sullivan, Michael B Atkins
Dec 27, 2005·Expert Review of Anticancer Therapy·Marta MandaràGian Luigi Cetto
Aug 7, 2010·Expert Opinion on Investigational Drugs·Ryan J Sullivan, Michael B Atkins
Nov 3, 2009·Clinics in Dermatology·Lucia B JilaveanuHarriet M Kluger
Sep 29, 2009·Critical Reviews in Oncology/hematology·Roger MouawadDavid Khayat
Oct 9, 2007·Cancer Treatment Reviews·Philip LuiThomas R Einarson
Jul 24, 2004·The British Journal of Dermatology·E RichtigJ Smolle
May 7, 2009·International Journal of Urology : Official Journal of the Japanese Urological Association·Georgios GakisArnulf Stenzl
Oct 26, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·D NashanA Enk
Oct 5, 2010·International Journal of Dermatology·Julieta Ruiz BeguerieRaúl P Valdez
Jun 1, 2013·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Annette PflugfelderUNKNOWN German Society of Dermatology
Dec 18, 2007·Seminars in Oncology·Hussein A Tawbi, John M Kirkwood
Jul 15, 2015·European Journal of Pharmacology·Mariana P C RibeiroJosé B A Custódio
Aug 4, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Alexander M M Eggermont, John M Kirkwood
Jul 30, 2015·HNO·C PföhlerC S L Müller
Sep 18, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Claus GarbeUNKNOWN European Organization of Research and Treatment of Cancer
Dec 5, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Claus GarbeAlexander Eggermont
Jul 2, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Claus GarbeUNKNOWN European Organisation for Research and Treatment of Cancer (EORTC)
Mar 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michele MaioUNKNOWN Thymosin Melanoma Investigation Group
Sep 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Agop Y BedikianUNKNOWN Oblimersen Melanoma Study Group
Feb 7, 2018·The Cochrane Database of Systematic Reviews·Sandro PasqualiSimone Mocellin
May 15, 2007·Melanoma Research·Claus Garbe, Thomas K Eigentler
Apr 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kateryna V LaikovaAnatoly V Kubyshkin
Mar 4, 2020·Research Synthesis Methods·Shannon CopeJeroen P Jansen
Aug 11, 2018·Journal of Cancer Research and Clinical Oncology·Harshita MishraSushama Talegaonkar
Dec 24, 2019·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Claus GarbeUNKNOWN European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization for Res
May 28, 2004·The British Journal of Surgery·A J HayesJ M Thomas

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