Phase II studies on docetaxel alone every third week, or weekly in combination with gemcitabine in patients with primary locally advanced, metastatic, or recurrent esophageal cancer.

Medical Oncology
M AlbertssonG Wagenius

Abstract

The purpose of these studies was to compare efficacy and toxicity of docetaxel alone with the combination of gemcitabine and docetaxel for treatment of metastatic esophageal carcinoma. These studies enrolled patients with histopathologically verified squamous cell carcinoma or adenocarcinoma of the esophagus or cardia. Between March 1997 and June 1999, 52 patients were enrolled in the initial Phase II study (Study 1). They were scheduled for treatment with docetaxel 100 mg/m2 every third week as a 1-h infusion. The second Phase II study between September 2000 and March 2003 included 65 patients (Study II). They were given docetaxel 30 mg/m2, administered as a 30-min i.v. infusion weekly for four times, followed by 2 weeks of rest, and gemcitabine starting with a dose of 750 mg/m2 (if well-tolerated 1,000 mg/m2) on days 1 and 15, followed by 3 weeks of rest. A new cycle began on day 36. Patients were premedicated with betamethasone 8 mg p.o. on the evening before, and 8 mg i.v. 30-60 min before the docetaxel infusion. Response was confirmed by computed tomography and assessed at 12 and 24 weeks. Toxicity was assessed according to WHO scales. In study I, 38 out of the 52 enrolled patients were valuable. Two patients experienced c...Continue Reading

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Citations

Nov 19, 2011·International Journal of Clinical Oncology·Ryoichi YanoMikio Masada
May 20, 2008·Surgical Oncology Clinics of North America·Toni LerutDirk Van Raemdonck
Jan 4, 2018·Future Oncology·Mohamad Bassam Sonbol, Tanios Bekaii-Saab
Jul 19, 2019·Journal of the National Comprehensive Cancer Network : JNCCN·Jaffer A AjaniLenora A Pluchino
Nov 29, 2017·The Cochrane Database of Systematic Reviews·Vincent T JanmaatManon Cw Spaander
Apr 22, 2015·World Journal of Gastroenterology : WJG·Min-Young LeeKeon Woo Park
Jan 25, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xinghua HanJianming Xu
Feb 16, 2020·Cold Spring Harbor Molecular Case Studies·Maxim SorokinAnton Buzdin
Nov 5, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nai-Bin ChenHui Liu

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