Phase II study of accelerated high-dose radiotherapy with concurrent chemotherapy for patients with limited small-cell lung cancer: Radiation Therapy Oncology Group protocol 0239.

International Journal of Radiation Oncology, Biology, Physics
R KomakiHak Choy

Abstract

To investigate whether high-dose thoracic radiation given twice daily during cisplatin-etoposide chemotherapy for limited small-cell lung cancer (LSCLC) improves survival, acute esophagitis, and local control rates relative to findings from Intergroup trial 0096 (47%, 27%, and 64%). Patients were accrued over a 3-year period from 22 US and Canadian institutions. Patients with LSCLC and good performance status were given thoracic radiation to 61.2 Gy over 5 weeks (daily 1.8-Gy fractions on days 1-22, then twice-daily 1.8-Gy fractions on days 23-33). Cisplatin (60 mg/m(2) IV) was given on day 1 and etoposide (120 mg/m(2) IV) on days 1-3 and days 22-24, followed by 2 cycles of cisplatin plus etoposide alone. Patients who achieved complete response were offered prophylactic cranial irradiation. Endpoints included overall and progression-free survival; severe esophagitis (Common Toxicity Criteria v 2.0) and treatment-related fatalities; response (Response Evaluation Criteria in Solid Tumors); and local control. Seventy-two patients were accrued from June 2003 through May 2006; 71 were evaluable (median age 63 years; 52% female; 58% Zubrod 0). Median survival time was 19 months; at 2 years, the overall survival rate was 36.6% (95% co...Continue Reading

References

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Citations

Dec 19, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Atsuya TakedaYukihiko Ozawa
Nov 2, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Giulia VeronesiMarco Alloisio
Dec 12, 2013·Cancer·Arya AminiRitsuko U Komaki
Jun 22, 2018·Breathe·Markus GlatzerPaul Martin Putora
Mar 15, 2018·La Radiologia medica·Patrizia CiammellaUNKNOWN On the behalf of Associazione Italiana Radioterapia Oncologica (AIRO)
Jan 20, 2020·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Gavin S JonesTricia M McKeever
Apr 25, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jeffrey A BogartEverett E Vokes
Nov 10, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Stephen G ChunJoe Y Chang

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