Phase II study of accelerated Linac-based SBRT in five consecutive fractions for localized prostate cancer

Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
Filippo AlongiRuggero Ruggieri

Abstract

The goal was to evaluate feasibility, side effects and biochemical no evidence of disease (bNED) after stereotactic body radiation therapy (SBRT) delivered on 5 consecutive days for localized prostate cancer (PC). The study was approved by the ethical committee and started in March 2014. Inclusion criteria were age ≤85 years, WHO performance status ≤2, histologically proven adenocarcinoma, low-intermediate risk, no previous surgery (except transurethral resection of the prostate), and a pre-SBRT International Prostatic Symptoms Score of 0-7. The radiotherapy regimen consisted of 35 Gy for low-risk and 37.5 Gy for intermediate-risk PC in 5 consecutive fractions. At the time of the analysis, 52 patients were recruited to the study (median age 73 years, range 55-83 years; median follow-up 34 months, range 12-49 months; 34 patients low-risk and 18 intermediate risk). The median initial prostate-specific antigen (PSA) was 5.9 ng/ml (range 1.8-15.7). Acute genitourinary (GU) toxicity was G0 (grade 0) 36/52 (69%), G1 11/52 (21%), G2 5/52 (10%), while acute rectal (GI) toxicity was G0 43/52 (83%), G1 8/52 (15%), G2 1/52 (2%). No acute toxicity ≥G3 was recorded. At the time of analysis late GU and GI toxicities were as follows: GU-G0 43...Continue Reading

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Citations

Dec 1, 2019·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Marcus BeckUNKNOWN Prostate Cancer Expert Panel of the German Society of Radiation Oncology (DEGRO) and the Working Party Radiation Oncology of
Sep 11, 2020·Expert Review of Anticancer Therapy·Francesco CucciaFilippo Alongi
May 14, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Francesco CucciaFilippo Alongi
May 15, 2020·La Radiologia medica·Alba FiorentinoMassimo Grimaldi
Aug 30, 2019·Technology in Cancer Research & Treatment·Leszek MiszczykAndrzej Tukiendorf
Dec 20, 2020·Journal of Applied Clinical Medical Physics·Damodar PokhrelWilliam St Clair
Jul 9, 2021·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Selvi DinçerMustafa Halil Akboru
Aug 20, 2021·Physical and Engineering Sciences in Medicine·Yutong ZhaoShahin Fattahi

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