Phase II study of celecoxib and trastuzumab in metastatic breast cancer patients who have progressed after prior trastuzumab-based treatments

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Chau T DangClifford Hudis

Abstract

Preclinical studies demonstrate a link between overexpression of HER-2/neu and cyclooxygenase-2 (COX-2) activity. To explore the possibility that COX-2 is a therapeutic target, we conducted a phase II study of celecoxib, a selective COX-2 inhibitor, and trastuzumab in patients with HER-2/neu-overexpressing metastatic breast cancer that had progressed while receiving trastuzumab. Eligible patients had bi-dimensionally measurable or evaluable HER-2/neu-overexpressing metastatic breast cancer. HER-2/neu overexpression, defined as 2+ or 3+ by the HercepTest, was required. Patients had to have progressed despite prior trastuzumab-based therapy. Treatment consisted of celecoxib (400 mg twice daily) and trastuzumab. Twelve patients were enrolled (42% status post 1 regimen for metastatic disease 58% status post > 2 prior regimens (range of 2-6). Eleven patients were evaluable. There were no responses. Median duration of treatment was 9 weeks. One patient had stable disease at 3 months but progressed at 6 months. A second patient stopped treatment at 3 months because of unresolved grade 2 rash, felt to be related to celecoxib. Toxicities were generally grade 1 or 2. One patient (8%) experienced grade 3 toxicity (abdominal pain). Celecox...Continue Reading

References

Jul 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B A GustersonR Reed
Oct 1, 1983·Journal of Clinical Immunology·J S Goodwin, J Ceuppens
Mar 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J BaselgaL Norton
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·M TsujiiR N DuBois
May 1, 1997·The Journal of Clinical Investigation·H ShengR N DuBois
Jun 7, 2000·The Journal of Clinical Investigation·C S WilliamsR N DuBois
Jun 30, 2000·The New England Journal of Medicine·G SteinbachG Kelloff
Feb 24, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A LebeauU Löhrs
Mar 30, 2001·The Journal of Biological Chemistry·C H LiuT Hla
May 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A D SeidmanC A Hudis
May 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R R TubbsT M Grogan
Jun 9, 2001·Endocrine-related Cancer·L R HoweA J Dannenberg
Dec 26, 2001·Journal of the National Cancer Institute·Y LuM Pollak
Mar 20, 2002·The Journal of Biological Chemistry·Kotha SubbaramaiahAndrew J Dannenberg
Feb 1, 2003·Trends in Pharmacological Sciences·Kotha Subbaramaiah, Andrew J Dannenberg
Jul 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N K AltorkiA J Dannenberg

❮ Previous
Next ❯

Citations

Oct 13, 2007·Breast Cancer Research and Treatment·Ferdinando MannelloEdward R Sauter
May 3, 2011·Breast Cancer Research and Treatment·Hee Sung KimDong-Young Noh
Apr 21, 2007·Nature Reviews. Cancer·Josie Ursini-SiegelWilliam J Muller
Jul 6, 2007·The New England Journal of Medicine·Clifford A Hudis
Jun 8, 2006·Journal of the National Cancer Institute·Sabine GröschGerd Geisslinger
Feb 16, 2005·Current Opinion in Obstetrics & Gynecology·Adnan Munkarah, Rouba Ali-Fehmi
Sep 20, 2005·Breast Cancer Research : BCR·Jill E KucabSandra E Dunn
Dec 12, 2012·Breast Cancer Research : BCR·Michelle D Holmes, Wendy Y Chen
Feb 18, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michelle D HolmesSusan E Hankinson
Jun 7, 2005·Expert Opinion on Therapeutic Targets·Ladislav Novotny, Thomas Szekeres
May 17, 2014·Expert Opinion on Emerging Drugs·Ana LluchJose-Alejandro Perez-Fidalgo
Jan 3, 2016·Drug Discovery Today·Miłosz RegulskiMarek Murias
Mar 28, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Muzammal HussainMuhammad Mahmood Mukhtar
Aug 13, 2010·Critical Reviews in Oncology/hematology·Monica GiovanniniEugenio Villa
Jan 16, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Gaston DemontyMartine Piccart
Sep 2, 2006·Critical Reviews in Oncology/hematology·D J A de GrootS de Jong
Jun 14, 2005·Biochemical Pharmacology·Khosrow Kashfi, Basil Rigas
Jul 15, 2015·BioMed Research International·Wan-Jhen WangShiu-Nan Chen
Mar 10, 2015·Critical Reviews in Oncology/hematology·G MustacchiL Scaltriti
Dec 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shanu ModiClifford A Hudis
Jun 10, 2017·Current Oncology Reports·Wendy Y Chen, Michelle D Holmes
Aug 16, 2005·British Journal of Cancer·N J Bundred, N L P Barnes
Jan 20, 2006·British Journal of Cancer·D MazharJ Waxman
Nov 21, 2017·Oncotarget·Sarah LangGudula Schmidt
Apr 5, 2005·The Journal of Pharmacology and Experimental Therapeutics·Basil Rigas, Khosrow Kashfi
Dec 4, 2014·Molecular and Clinical Oncology·Lucia HiľovskáPeter Fedoročko
Jan 1, 2009·Breast Cancer : Basic and Clinical Research·Klaus H BaumannUwe Wagner
Feb 10, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Frida PonthanJohn I Johnsen
Jan 30, 2018·The Journal of Physical Chemistry. B·José Pedro Cerón-CarrascoAlberto Requena
Sep 19, 2021·NPJ Breast Cancer·Harshit ShahVenkatachalem Sathish

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.