Phase II study of doxercalciferol for the treatment of myelodysplastic syndrome.

Leukemia & Lymphoma
Adam PetrichMark Juckett

Abstract

We conducted a phase II trial of doxercalciferol, a vitamin D2 analogue, in 15 patients with MDS. Each received doxercalciferol 12.5 microg orally daily for 12 weeks. Nine of 15 patients completed the prescribed course and of these, six had stable disease. No patient had a response (IWG criteria) and overall eight patients experienced progressive disease while on therapy. Two patients with chronic myelomonocytic leukemia (CMML) had a marked rise in monocytes on study. Overall the treatment was well tolerated. One patient was removed from study due to hypercalcemia. We conclude that short-term treatment with doxercalciferol has limited activity in patients with MDS.

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Citations

Jun 20, 2013·Nutrients·Aric C Hall, Mark B Juckett
Jan 19, 2008·Leukemia & Lymphoma·Ryoko OkamotoPhillip Koeffler
Dec 7, 2010·Best Practice & Research. Clinical Haematology·H Phillip Koeffler
Feb 20, 2015·Journal of Cellular Biochemistry·George P StudzinskiMichael Danilenko
Aug 4, 2015·Chinese Journal of Natural Medicines·Rachel A NessWei Li
Sep 1, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Xuening WangGeorge P Studzinski
Dec 24, 2011·Cancer Letters·Minji KimMaurizio Chiriva-Internati
Oct 16, 2016·European Journal of Haematology·Paige M KullingThomas P Loughran
Feb 9, 2017·Experimental Hematology·Huynh CaoChien-Shing Chen
Apr 14, 2009·The International Journal of Artificial Organs·Sandro MazzaferroRaffaella Lavini
Aug 24, 2020·European Journal of Medicinal Chemistry·Jingxuan ChenJianjun Chen

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